3,4,5-三甲氧基苯胺合成路线 （共 68 条）
反应条件
1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 24 h / |Reflux 2: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-diaza-bicyclo[2.2.2]octane; triethylamine / methanol / 3 h / |Reflux; |Green chemistry View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 355, # 1 p. 81 - 86
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 22 p. 5864 - 5869
反应条件
1: nitric acid 2: tin dichloride; hydrochloric acid View Scheme
参考文献
Chemische Berichte, , vol. 21, p. 615
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 832 - 834
反应条件
copper diacetate; air; palladium diacetate in toluene P=760 Torr; 2 h; Heating;
参考文献
Orito, Kazuhiko; Miyazawa, Mamoru; Nakamura, Takatoshi; Horibata, Akiyoshi; Ushito, Harumi; Nagasaki, Hideo; Yuguchi, Motoki; Yamashita, Satoshi; Yamazaki, Tetsuro; Tokuda, Masao
Journal of Organic Chemistry, 2006 , vol. 71, # 16 p. 5951 - 5958
反应条件
1: 54 percent / acetonitrile; H2O / 36 h / Irradiation View Scheme
参考文献
Protti, Stefano; Fagnoni, Maurizio; Albini, Angelo
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 15 p. 2868 - 2871
参考文献
Chemische Berichte, , vol. 63, p. 208,221
Journal of the Chemical Society, , p. 178
反应条件
1: With triethylamine in ethanol T=20°C; 2: With 4-(N,N-dimethlyamino)pyridine; di-tert-butyl dicarbonate in ethanol T=20°C; 0.25 h; Further stages.;
参考文献
Tetrahedron Letters, , vol. 49, # 19 p. 3117 - 3119
反应条件
1: α-phenylbenzeneacetic acid; 4-methyl-benzoic acid With thionyl chloride Combinatorial reaction / High throughput screening (HTS); 2: 2-(4-hydroxyphenyl)ethylamine; 1-adamantaneamine; 2-(4-methylphenyl)-ethylamine; 2-(3,4-dimethoxyphenyl)-ethylamine; phenethylamine; 2-(4-methoxy-phenyl)ethylamine; 3,4,5-trimethoxy-phenylamine; 2-(3-methoxy-phenyl)-ethylamine; 1-amino-2-(2-methoxyphenyl)ethane; (1R*,2S*)-2-methylamino-1-phenyl-1-propanol
参考文献
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Patent: WO2005/44191 A2, 2005 ;
Location in patent: Figure 12 ;
反应条件
sodium hydroxide in 1,4-dioxane Heating;
参考文献
Coyne,W.E.; Cusic,J.W.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 6 p. 1208 - 1213
