(2E)-3-(4-硝基苯基)-2-丙烯酸乙酯合成路线 （共 77 条）
反应条件
1: With potassium carbonate
Horner-Wadsworth-Emmons olefination; 6 h; Neat (no solvent)high-speed ball milling;
2: With Oxonereg;
12 h; Neat (no solvent)high-speed ball milling; optical yield given as percent dediastereoselective reaction;
参考文献
Shearouse, William C.; Korte, Chelsea M.; Mack, James
Green Chemistry, 2011 , vol. 13, # 3 p. 598 - 601
反应条件
1: 88 percent / piperidine, pyridine / Heating
2: 71 percent / conc. sulfuric acid / 5 h / Heating
View Scheme
参考文献
Potapov, V. M.; Gracheva, R. A.; Sivov, N. A.; Savina, S. A.; Sivova, L. A.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 9 p. 1694 - 1699
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 9 p. 1876 - 1881
反应条件
1: thionyl chloride, DMF / toluene / 60 - 70 °C
2: 55 percent / tri-n-butylamine, palladium acetate / xylene / 1 h / 120 °C
View Scheme
参考文献
Blaser, Hans-Ulrich; Spencer, Alwyn
Journal of Organometallic Chemistry, 1982 , vol. 233, # 2 p. 267 - 274
反应条件
aliquat 366; triethylamine; palladium on activated charcoal in water; toluene
T=100°C; Heck reaction; 3 h; Product distribution; Further Variations:Reagentstime;
参考文献
Perosa, Alvise; Tundo, Pietro; Selva, Maurizio; Zinovyev, Sergei; Testa, Alberto
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 15 p. 2249 - 2252
反应条件
1: trans-[Ru(Mes-NP)2(CH3CN)2](BF4)2; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / 1,2-dichloro-ethane; toluene / 6 h / 80 °C / Inert atmosphere
2: trans-[Ru(Mes-NP)2(CH3CN)2](BF4)2; triphenylphosphine / 1,2-dichloro-ethane; toluene / 1 h / 80 °C / Inert atmosphere
View Scheme
参考文献
Saha, Biswajit; Rahaman, S. M. Wahidur; Sinha, Arup; Bera, Jitendra K.
Australian Journal of Chemistry, 2011 , vol. 64, # 5 p. 583 - 589
反应条件
nitric acid
T=25 - 30°C;
参考文献
Guastalla
Atti della Accademia delle Scienze di Torino, Classe di Scienze Fisiche, Matematiche e Naturali, vol. 63, p. 129
Chem. Zentralbl., 1928 , vol. 99, # II p. 984
反应条件
boron trifluoride diethyl etherate in diethyl ether
参考文献
Vieregge,H. et al.
Recueil des Travaux Chimiques des Pays-Bas, 1966 , vol. 85, p. 929 - 951
反应条件
lithium diisopropyl amide
1.) THF, hexane, -78 deg C, 1 h, 2.) a) from -78 deg C to room temp., 1 h, b) room temp., 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tsuge, Otohiko; Sone, Kazuhiro; Urano, Satoshi; Matsuda, Koyo
Journal of Organic Chemistry, 1982 , vol. 47, # 26 p. 5171 - 5177
反应条件
1: conc. HNO3 / 0 °C
2: conc. H2SO4 / Heating
View Scheme
参考文献
Cristiano, M. Lurdes S.; Johnstone, Robert A. W.; Price, Peter J.
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 12 p. 1453 - 1459
反应条件
sodium ethanolate in ethanol
T=20°C; Rate constant;
参考文献
Larsen, Rolf Olaf; Aksnes, Gunnar
Phosphorus and Sulfur and the Related Elements, 1983 , vol. 15, p. 219 - 228
