1,3-二甲基-1,3-二氢-2H-吲哚-2-酮合成路线 （共 38 条）
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Julian; Printy
Journal of the American Chemical Society, 1949 , vol. 71, p. 3206
参考文献
Julian; Printy
Journal of the American Chemical Society, 1949 , vol. 71, p. 3206
反应条件
aluminium trichloride
T=120°C; 0.25 h;
参考文献
Mekhael, Maged K. G.; Heimgartner, Heinz
Helvetica Chimica Acta, 2003 , vol. 86, # 8 p. 2805 - 2813
反应条件
hydrogenchloride; dimethyl sulfoxide in water
T=20°C; 1 h; Inert atmosphere;
参考文献
Trost, Barry M.; Xie, Jia; Sieber, Joshua D.
Journal of the American Chemical Society, 2011 , vol. 133, # 50 p. 20611 - 20622
反应条件
1.1: NaH / dimethylformamide / 1 h / 20 °C
1.2: dimethylformamide / 0 - 20 °C
2.1: 2.283 g / aq. HCl / dimethylsulfoxide
View Scheme
参考文献
Shaw, Scott A.; Aleman, Pedro; Christy, Justin; Kampf, Jeff W.; Va, Porino; Vedejs, Edwin
Journal of the American Chemical Society, 2006 , vol. 128, # 3 p. 925 - 934
反应条件
dihydrogen peroxide; sodium chloride; chloroperoxidase in phosphate buffer; acetone
T=20°C; pH=2.75; 4 h;
参考文献
Alvarez, Ricardo G.; Hunter, Iain S.; Suckling, Colin J.; Thomas, Michael; Vitinius, Ute
Tetrahedron, 2001 , vol. 57, # 40 p. 8581 - 8587
反应条件
1: With disodium hydrogenphosphate; sodium hydroxide in methanol
1 h;
2: With Oxonereg; in methanol
T=20°C; 1 h;
参考文献
Li, Ya-Min; Wei, Xiao-Hong; Li, Xi-An; Yang, Shang-Dong
Chemical Communications, 2013 , vol. 49, # 99 p. 11701 - 11703
反应条件
didodecanoyl peroxide; sodium hydrogencarbonate in benzene
Cyclization; Heating;
参考文献
Ollivier; Bark; Renaud
Synthesis, 2000 , # 11 p. 1598 - 1602
反应条件
1: N-methyl-2-indolinone With N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium hexamethyldisilazane in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: methyl iodide T=-78°C; 1 h;
参考文献
Nakazawa, Norio; Tagami, Keiko; Iimori, Hitoshi; Sano, Shigeki; Ishikawa, Tsutomu; Nagao, Yoshimitsu
Heterocycles, 2001 , vol. 55, # 11 p. 2157 - 2170
反应条件
2: 45 percent / LDA / tetrahydrofuran / 4 h / Ambient temperature; Irradiation
View Scheme
参考文献
Goehring, R. Richard; Sachdeva, Yesh P.; Pisipati, Jyothi S.; Sleevi, Mark C.; Wolfe, James F.
Journal of the American Chemical Society, 1985 , vol. 107, # 2 p. 435 - 443
