8,9-二氢-6H-吡啶并[2,1-b]喹唑啉-11(7h)-酮合成路线 （共 42 条）
反应条件
1: 1,4-dioxane / 6 h / 30 °C
2: [{(η5-C5Me5)IrCl}2(μ-Cl)2]; trifluorormethanesulfonic acid / anhydrous xylene / 36 h / Inert atmosphere; Reflux
View Scheme
参考文献
Fang, Jie; Zhou, Jianguang
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 12 p. 2389 - 2391
反应条件
1: [{(η5-C5Me5)IrCl}2(μ-Cl)2] / anhydrous xylene / 22 h / Reflux
2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 3 h / 20 °C
View Scheme
参考文献
Fang, Jie; Zhou, Jianguang
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 12 p. 2389 - 2391
反应条件
1: 1,4-dioxane / 6 h / 30 °C
2: [{(η5-C5Me5)IrCl}2(μ-Cl)2]; trifluorormethanesulfonic acid / anhydrous xylene / 36 h / Inert atmosphere; Reflux
View Scheme
参考文献
Fang, Jie; Zhou, Jianguang
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 12 p. 2389 - 2391
反应条件
1: [{(η5-C5Me5)IrCl}2(μ-Cl)2] / toluene / 48 h / Inert atmosphere; Reflux
2: potassium carbonate / methanol; water / 4 h / 20 °C
3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 3 h / 20 °C
View Scheme
参考文献
Fang, Jie; Zhou, Jianguang
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 12 p. 2389 - 2391
反应条件
in toluene
2 h; Heating;
参考文献
Mahindroo, Neeraj; Ahmed, Zabeer; Bhagat, Asha; Bedi, Kasturi Lal; Khajuria, Ravi Kant; Kapoor, Vijay Kumar; Dhar, Kanaya Lal
Medicinal Chemistry Research, 2005 , vol. 14, # 6 p. 347 - 368
反应条件
1: Et3N / tetrahydrofuran / 20 °C
2: 90 percent / sodium iodide; acetic acid / 3 h / Heating
View Scheme
参考文献
Kamal, Ahmed; Ramana, A. Venkata; Reddy, K. Srinivasa; Ramana, K. Venkata; Hari Babu; Prasad, B. Rajendra
Tetrahedron Letters, 2004 , vol. 45, # 44 p. 8187 - 8190
反应条件
1: benzene; dioxane / 3 h / 20 °C
2: H2SO4 / 8 h / 20 °C
3: 2.484 g / NaBH4 / tetrahydrofuran / 3 h / Heating
4: 81 percent / NaH; p-toluenesulfonyl chloride / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Mhaske, Santosh B.; Argade, Narshinha P.
Tetrahedron, 2004 , vol. 60, # 15 p. 3417 - 3420
反应条件
1: 2.484 g / NaBH4 / tetrahydrofuran / 3 h / Heating
2: 81 percent / NaH; p-toluenesulfonyl chloride / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Mhaske, Santosh B.; Argade, Narshinha P.
Tetrahedron, 2004 , vol. 60, # 15 p. 3417 - 3420
反应条件
1: H2SO4 / 8 h / 20 °C
2: 2.484 g / NaBH4 / tetrahydrofuran / 3 h / Heating
3: 81 percent / NaH; p-toluenesulfonyl chloride / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Mhaske, Santosh B.; Argade, Narshinha P.
Tetrahedron, 2004 , vol. 60, # 15 p. 3417 - 3420
反应条件
chromium(VI) oxide; hydrogenchloride; sulfuric acid
Multistep reaction;
参考文献
Smith, Terence A.; Croker, Stephen J.; Loeffler, R. S. Thomas
Phytochemistry (Elsevier), 1986 , vol. 25, # 3 p. 683 - 690
