(S)-4-异丙基恶唑-2,5-二酮合成路线 （共 34 条）
反应条件
1: 1.) NEt3 / 1.) CHCl3; 2.) CHCl3, THF, 4 h, -70 deg C then 1 h, room temp. 2: toluene / 20 h / Heating View Scheme
参考文献
Weihrauch, Thomas; Leibfritz, Dieter
Liebigs Annalen der Chemie, 1985 , # 9 p. 1917 - 1921
反应条件
triethylamine 1) THF, CH2Cl2, -70 deg C, 3h, 2) toluene, 12h, reflux; Yield given. Multistep reaction;
参考文献
Thomas, Neil R.; Gani, David
Tetrahedron, 1991 , vol. 47, # 3 p. 497 - 506
反应条件
(i) aq. K2B4O7, (ii) /BRN= 81948/, aq. KOH, (iii) H2SO4; Multistep reaction;
参考文献
Hirschmann,R. et al.
Journal of Organic Chemistry, 1967 , vol. 32, p. 3415 - 3425
反应条件
1: With triethylamine in tetrahydrofuran; chloroform T=-70°C; 2: in toluene Heating; Further stages.;
参考文献
Ma; Liu; Li; Flippen-Anderson; Yu; Cook
Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4525 - 4542
反应条件
triethylamine in tetrahydrofuran; chloroform 1.) -70 deg C, 3 h, 2.) RT, 2 h;
参考文献
Allen; Hamaker; La Loggia; Cook
Synthetic Communications, 1992 , vol. 22, # 14 p. 2077 - 2102
反应条件
1: Et3N / CHCl3; tetrahydrofuran / 13 h / -78 - -20 °C 2: toluene / 24 h / Heating View Scheme
参考文献
Schoellkopf, Ulrich
Tetrahedron, 1983 , vol. 39, # 12 p. 2085 - 2092
反应条件
1: 1.) NEt3 / 1.) CHCl3; 2.) CHCl3, THF, 4 h, -70 deg C then 1 h, room temp. 2: toluene / 20 h / Heating 3: 83 percent / CH2Cl2 / 3.5 h / Ambient temperature 4: 1.) 1.37 M n-BuLi / 1.) hexane, THF, 20 min, -70 deg C; 2.) hexane, THF, 12 h, -70 deg C 5: 0.25 N aq. HCl / 48 h / Ambient temperature View Scheme
参考文献
Weihrauch, Thomas; Leibfritz, Dieter
Liebigs Annalen der Chemie, 1985 , # 9 p. 1917 - 1921
反应条件
1: triethylamine / acetonitrile / 4 h / 20 °C
2: H2 / Pd / acetic acid; 2-methyl-propan-2-ol; H2O
View Scheme
参考文献
Oya, Masanao; Takahashi, Tomoko
Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 9 p. 2705 - 2707
反应条件
1: Et3N / CHCl3; tetrahydrofuran / 13 h / -78 - -20 °C
2: toluene / 24 h / Heating
3: CH2Cl2 / 6 h
4: 2M aq. HCl / 12 h
View Scheme
参考文献
Oya, Masanao; Takahashi, Tomoko
Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 9 p. 2705 - 2707
反应条件
1: triethylamine / tetrahydrofuran; CHCl3 / 1.) 3 h, - 70 degC, 2.) 30 min, room temp.
2: toluene / 12 h / Heating
3: 89 percent / CH2Cl2 / 72 h
View Scheme
参考文献
Schoellkopf; Groth; Westphalen; Deng
Synthesis, 1981 , vol. No. 12, p. 969 - 973
