2-(4-溴苯氧基)-N,N-二甲基乙胺合成路线 （共 21 条）
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; palladium diacetate in tetrahydrofuran T=60°C; Suzuki-Miyaura coupling; 24 h; Inert atmosphere; optical yield given as percent de;
参考文献
Ishida, Naoki; Shimamoto, Yasuhiro; Murakami, Masahiro
Organic Letters, 2009 , vol. 11, # 23 p. 5434 - 5437
反应条件
n-butyllithium; triethylamine; trifluoroacetic anhydride in tetrahydrofuran; hexane T=-50 - 100°C; 1.33333 h; Inert atmosphereFlow reactor; Overall yield = 84 percent; Overall yield = 12.43 g;
参考文献
Murray, Philip R. D.; Browne, Duncan L.; Pastre, Julio C.; Butters, Chris; Guthrie, Duncan; Ley, Steven V.
Organic Process Research and Development, 2013 , vol. 17, # 9 p. 1192 - 1208
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water Suzuki-Miyaura cross-coupling; Heating;
参考文献
McKinley, Neola F.; O'Shea, Donal F.
Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9552 - 9555
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; palladium diacetate in tetrahydrofuran T=60°C; Suzuki-Miyaura coupling; 24 h; Inert atmosphere; optical yield given as percent de;
参考文献
Ishida, Naoki; Shimamoto, Yasuhiro; Murakami, Masahiro
Organic Letters, 2009 , vol. 11, # 23 p. 5434 - 5437
反应条件
n-butyllithium; triethylamine; trifluoroacetic anhydride in tetrahydrofuran; hexane T=-50 - 100°C; 1.33333 h; Inert atmosphereFlow reactor; Overall yield = 84 percent; Overall yield = 12.43 g;
参考文献
Murray, Philip R. D.; Browne, Duncan L.; Pastre, Julio C.; Butters, Chris; Guthrie, Duncan; Ley, Steven V.
Organic Process Research and Development, 2013 , vol. 17, # 9 p. 1192 - 1208
反应条件
tetrakis(triphenylphosphine) palladium(0) 1.) hexane, toluene, 90 deg C, 24 h, 2.) THF, reflux, 24 h; Yield given. Multistep reaction;
参考文献
Al-Hassan
Synthesis, 1987 , vol. No. 9, p. 816 - 817
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water Suzuki-Miyaura cross-coupling; Heating;
参考文献
McKinley, Neola F.; O'Shea, Donal F.
Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9552 - 9555
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, a) from -78 deg C to RT, b) reflux, 3 h
2: concd. HCl / ethanol / 3 h / Heating
View Scheme
参考文献
McCague; Kuroda; Leclercq; Stoessel
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 2053 - 2059
反应条件
hydrogenchloride; ethylmagnesium bromide
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Ruenitz, Peter C.; Bagley, Jerome R.; Mokler, Corwin M.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1056 - 1060
反应条件
1.1: Mg / tetrahydrofuran / 4 h / 30 °C
1.2: 65 percent / tetrahydrofuran / Heating
2.1: 89 percent / aq. HCl / methanol / Heating
View Scheme
参考文献
El-Wakil, Hoda A.
Organic Preparations and Procedures International, 1991 , vol. 23, # 6 p. 754 - 757
