2,2,-二甲基-2H-苯并吡喃合成路线 （共 66 条）
反应条件
sodium tert-pentoxide in toluene
1.) room temp, 10 min; 2.) reflux, 30 min;
参考文献
Begasse, B.; Corre, M. Le
Tetrahedron, 1980 , vol. 36, p. 3409 - 3412
反应条件
toluene-4-sulfonic acid; hydroquinone in benzene
2.5 h; Heating;
参考文献
Boyd, Derek R.; Sharma, Narain D.; Boyle, Rosemary; Evans, Timothy A.; Malone, John F.; McCombe, Kenneth M.; Dalton, Howard; Chima, Jagdeep
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 14 p. 1757 - 1765
反应条件
1: pyrrolidine / acetonitrile / 8 h / 45 °C
2: NaBH4 / methanol / 20 °C
3: p-TsOH*H2O / toluene / 22 h / 100 °C
View Scheme
参考文献
Gerlach; Brendel; Lang; Paulus; Weidmann; Brueggemann; Busch; Suessbrich; Bleich; Greger
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3831 - 3837
反应条件
1: 54 percent / BBr3 / CH2Cl2 / 0.08 h / 0 °C
2: 87 percent / Ambient temperature; macroelectrolysis: mercury pool working electrode, tetraethylammonium p-toluenesulfonate supporting electrolyte
View Scheme
参考文献
Tsukayama, Masao
Heterocycles, 1997 , vol. 45, # 6 p. 1131 - 1142
反应条件
1: iodine / 150 °C
2: N-bromo-succinimide; tetrachloromethane; dibenzoyl peroxide / Erwaermen des Reaktionsprodukts mit Natriumaethylat in Benzol
View Scheme
参考文献
Clemo; Ghatge
Journal of the Chemical Society, 1955 , p. 4347
反应条件
1: 91 percent / NaIO4 / ethanol; H2O / 24 h / 0 °C
2: 95 percent / toluene / 2 h / Heating
View Scheme
参考文献
Inoue, Seiichi; Ikeda, Hiroshi; Sato, Shuichi; Horie, Kiyohiro; Ota, Tomomi; et al.
Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5495 - 5497
反应条件
1: 70 percent / BF3*OEt2
2: 91 percent / NaIO4 / ethanol; H2O / 24 h / 0 °C
3: 95 percent / toluene / 2 h / Heating
View Scheme
参考文献
Inoue, Seiichi; Ikeda, Hiroshi; Sato, Shuichi; Horie, Kiyohiro; Ota, Tomomi; et al.
Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5495 - 5497
反应条件
1: CuCl2·2H2O; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 20 °C
2: / 1,2-dichloro-ethane / 26 h / 70 °C
View Scheme
参考文献
Efe, Christina; Lykakis, Ioannis N.; Stratakis, Manolis
Chemical Communications, 2011 , vol. 47, # 2 p. 803 - 805
参考文献
Smith; Ruoff
Journal of the American Chemical Society, 1940 , vol. 62, p. 145,147
反应条件
1: 14 percent / ytterbium triflate hydrate / CH2Cl2 / 12 h / 25 °C
2: PTSA / toluene / 1 h / Heating
View Scheme
参考文献
Prado, Soizic; Janin, Yves L.; Bost, Pierre-Etienne
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1605 - 1608
