2-叔丁基-1,3,4-恶二唑合成路线 （共 4 条）
反应条件
toluene-4-sulfonic acid T=16 - 70°C; 2 h; Large scale;
参考文献
Kim, Bong Chan; Kim, Kyu-Young; Lee, Hee Bong; Shin, Hyunik
Organic Process Research and Development, 2008 , vol. 12, # 4 p. 626 - 631
参考文献
Accuthera, Inc.
Patent: US2009/156509 A1, 2009 ;
US 20090156509 A1
反应条件
1: 60 percent / hydrazine hydrate / 28 h / Heating 2: 69 percent / p-toluenesulfonic acid monohydrate / 80 - 120 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 8 p. 1268 - 1285
反应条件
1: hydrazine hydrate; titanium(IV) isopropylate / toluene; butan-1-ol / 18 - 115 °C / |Dean-Stark; |Large scale 2: toluene-4-sulfonic acid / 2 h / 16 - 70 °C / |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 12, # 4 p. 626 - 631
