2-氯-5-硝基苯甲酸合成路线 （共 155 条）
反应条件
copper; potassium carbonate in N,N-dimethyl-formamide T=25°C; Ullmann condensation; 0.25 h; ultrasonic irradiation;
参考文献
Docampo, Maite L.; Pellon, Rolando F.; Estevez-Braun, Ana; Ravelo, Angel G.
European Journal of Organic Chemistry, 2007 , # 24 p. 4111 - 4115
反应条件
1: 93.1 percent / phosphorus pentachloride / benzene / 3 h / Heating 2: 85.4 percent / aluminium chloride / 1 h / Heating 3: 56.1 percent / KOH / H2O / 5 h / 150 - 160 °C View Scheme
参考文献
Hayashi, Ikuo; Ogihara, Keizo; Shimizu, Kiyoshi
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 8 p. 2432 - 2437
反应条件
1: 85 percent / PCl5 / chlorobenzene / 1.) RT, 24 h, 2.) 50 deg C, 1 h 2: AlCl3 / 24 h / Ambient temperature View Scheme
参考文献
Kumazawa, Eiji; Hirotani, Kenji; Burford, S. Clifford; Kawagoe, Keiichi; Miwa, Tamotsu; Mitsui, Ikuo; Ejima, Akio
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 9 p. 1470 - 1474
反应条件
1: copper diacetate; potassium carbonate / 2 h / 185 °C / |Inert atmosphere 2: trichlorophosphate / 5 h / 140 °C / |Inert atmosphere View Scheme
参考文献
Almac Sciences (Scotland) Limited; RAMAGE, Robert; MALTMAN, Beatrice; COTTON, Graham; COUTURIER, Sarah, Claire, Monique; MCMORDIE, Robert, Austin, Simms
Patent: EP1940965 B1, 2014 ;
反应条件
1: 2-carboxy-4-nitro-chlorobenzene With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 0.166667 h; 2: 4-amino-phenol in tetrahydrofuran Heating; Further stages.;
参考文献
Kumar, Anil; Narasimhan, Balasubramanian; Kumar, Devinder
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 12 p. 4113 - 4124
反应条件
1: With hydrazine in ethanol T=100°C; 3.5 h; 2: With hydrogenchloride; water in ethanol pH=~ 5.0;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2008/79759 A1, 2008 ;
Location in patent: Page/Page column 128-129 ;
WO 2008/079759 A1
反应条件
1: copper diacetate; potassium carbonate / 2 h / 185 °C / |Inert atmosphere 2: trichlorophosphate / 5 h / 140 °C / |Inert atmosphere 3: phenol; (NH4)2CO3 / 1 h / 70 - 120 °C / |Inert atmosphere 4: sodium hydroxide / water / 2 h / 20 °C 5: palladium/alumina; ammonium formate / ethyl acetate; methanol / 1.33 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Almac Sciences (Scotland) Limited; RAMAGE, Robert; MALTMAN, Beatrice; COTTON, Graham; COUTURIER, Sarah, Claire, Monique; MCMORDIE, Robert, Austin, Simms
Patent: EP1940965 B1, 2014 ;
反应条件
N,N-diethyl-m-phenylenediamine; copper; sodium carbonate weiteres Reagens: Isoamylalkohol;
参考文献
Tuttle
Journal of the American Chemical Society, 1923 , vol. 45, p. 1914
参考文献
Tuttle
Journal of the American Chemical Society, 1923 , vol. 45, p. 1914
反应条件
EDC-polymer in tetrahydrofuran T=20°C; 4 h;
参考文献
Hwang, Jong Yeon; Smithson, David; Connelly, Michele; Maier, Julie; Zhu, Fangyi; Guy, Kiplin R.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 149 - 152
