N-异丙基-2-硝基苯胺合成路线 （共 13 条）
反应条件
N-ethyl-N,N-diisopropylamine in dimethyl sulfoxide T=80°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOYER, Stephen, James; BURKE, Jennifer; GUO, Xin; KIRRANE JR., Thomas, Martin; SNOW, Roger, John; ZHANG, Yunlong
Patent: WO2011/71725 A1, 2011 ;
Location in patent: Page/Page column 68 ;
WO 2011/071725 A1
反应条件
dimethylsulfide borane complex in dichloromethane; acetic acid T=20°C; 24 h;
参考文献
Figge, Axel; Altenbach, Hans J.; Brauer, David J.; Tielmann, Patrick
Tetrahedron Asymmetry, 2002 , vol. 13, # 2 p. 137 - 144
反应条件
sodium tris(acetoxy)borohydride; acetic acid in 1,2-dichloro-ethane T=20°C; 45 h;
参考文献
Reddy, T. Jagadeeswar; Leclair, Michael; Proulx, Melanie
Synlett, 2005 , # 4 art. no. S07004ST, p. 583 - 586
参考文献
Hawkins, David; Lindley, John M.; McRobbie, Ian M.; Meth-Cohn, Otto
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2387 - 2391
反应条件
1: 2-nitro-aniline With acetic acid in dichloromethane; acetone 2: dimethylsulfide borane complex T=0°C;
参考文献
Tronnier, Alexander; Metz, Stefan; Wagenblast, Gerhard; Muenster, Ingo; Strassner, Thomas
Dalton Transactions, 2014 , vol. 43, # 8 p. 3297 - 3305
反应条件
sodium hydride in dimethyl sulfoxide
参考文献
Chakrabarty, Manas; Karmakar, Sulakshana; Mukherjee, Ratna; Arima, Shiho; Harigaya, Yoshihiro
Monatshefte fur Chemie, 2009 , vol. 140, # 4 p. 375 - 380
反应条件
1: dichloromethane; acetic acid / 0.08 h / 20 °C / |Inert atmosphere 2: borane-THF / dichloromethane; acetic acid; tetrahydrofuran / 16 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Chen, Wen-Ching; Hsu, Yu-Chen; Lee, Ching-Yu; Yap, Glenn P. A.; Ong, Tiow-Gan
Organometallics, 2013 , vol. 32, # 8 p. 2435 - 2442
参考文献
Jacobsen, E. Jon; Stelzer, Lindsay S.; Belonga, Kenneth L.; Carter, Donald B.; Im, Wha Bin; Sethy, Vimala H.; Tang, Andrew H.; Von Voigtlander, Philip F.; Petke, James D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3820 - 3836
反应条件
borane-pyridine complex; trifluoroacetic acid 1.) toluene, RT, 1 h, 2.) toluene, 20 h; Yield givenMultistep reaction;
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
反应条件
TEA in hexane Ambient temperaturevariation of temperature and catalysts; Product distributionKineticsRate constant;
参考文献
Chiacchiera, Stella M.; Singh, Joaquin O.; Anunziata, Jorge D.; Silber, Juana J.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987 , p. 987 - 994
