6-溴-2-(三氟乙酰基)-1,2,3,4-四氢异喹啉合成路线 （共 8 条）
反应条件
sulfuric acid in acetic acid T=20°C; 72 h;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2008/171754 A1, 2008 ;
Location in patent: Page/Page column 102 ;
US 20080171754 A1
反应条件
sulfuric acid; acetic acid T=20°C; 20 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/60882 A1, 2004 ;
Location in patent: Page 36 ;
WO 2004/060882 A1
反应条件
triethylamine in dichloromethane T=0 - 20°C; 1 h;
参考文献
Kureha Corporation
Patent: EP1724263 A1, 2006 ;
Location in patent: Page/Page column 40 ;
反应条件
formaldehyd; sulfuric acid in water T=20°C; 16 h;
参考文献
NOVARTIS AG
Patent: WO2008/76954 A2, 2008 ;
Location in patent: Page/Page column 50 ;
WO 2008/076954 A2
反应条件
sulfuric acid; acetic acid T=0 - 20°C; 16.5 h;
参考文献
MERCK SERONO S.A.; QUATTROPANI, Anna; BAKER-GLENN, Charles; BLACKABY, Wesley; KNIGHT, Chris
Patent: WO2010/142628 A1, 2010 ;
Location in patent: Page/Page column 158 ;
WO 2010/142628 A1
反应条件
1: (R)-4-bromo-α-phenethylamine; trifluoroacetic anhydride 2: formaldehyd Acidic conditions;
参考文献
Pfizer Inc
Patent: US2005/182079 A1, 2005 ;
Location in patent: Page/Page column 12 ;
反应条件
water; sodium carbonate in methanol Heating / reflux;
参考文献
WO2008/76954 A2, ;
Page/Page column 50 ;
WO 2008/076954 A2
反应条件
water; sodium carbonate in methanol Heating / reflux;
参考文献
WO2008/76954 A2, ;
Page/Page column 50 ;
WO 2008/076954 A2
