2-羟基-3-甲基-丁酸-1,1-二甲基乙酸乙酯合成路线 （共 3 条）
参考文献
Losse,G.; Raue,H.
Chemische Berichte, 1965 , vol. 98, p. 1522 - 1530
反应条件
1: α-hydroxy-isovaleric acid t-butyl ester With [Cu(S,S)-t-Bu-box]OTf2 in dichloromethane T=0°C; 0.166667 h; Inert atmosphere; 2: 1-isocyanatopropane in dichloromethane T=0°C; 1 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Kurono, Nobuhito; Ohtsuga, Kentaro; Wakabayashi, Masanori; Kondo, Tadahiro; Ooka, Hirohito; Ohkuma, Takeshi
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 10312 - 10318
反应条件
1: α-hydroxy-isovaleric acid t-butyl ester With [Cu(S,S)-t-Bu-box]OTf2 in dichloromethane
T=0°C; 0.166667 h; Inert atmosphere;
2: 1-isocyanatopropane in dichloromethane
T=0°C; 1 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Kurono, Nobuhito; Ohtsuga, Kentaro; Wakabayashi, Masanori; Kondo, Tadahiro; Ooka, Hirohito; Ohkuma, Takeshi
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 10312 - 10318
