2,4-二甲基-5-醛基-1H-吡咯-3-羧酸合成路线

参考文献

SCINOPHARM TAIWAN, LTD.; Henscheke, Julian P.; Chen, Yung-Fa
Patent: US2013/190512 A1, 2013 ;
Location in patent: Paragraph 0088 ;

123-75-1四氢吡咯+

253870-02-92,4-二甲基-5-醛基-1H-吡咯-3-羧酸+

56341-41-45-氟吲哚-2-酮

356068-93-45-((Z)-(5-氟-2-氧代吲哚烷-3-亚基)甲基)-2,4-二甲基-1H-吡咯-3-羧酸

参考文献

Tang, Peng Cho; Miller, Todd A.; Li, Xiaoyuan; Sun, Li; Wei, Chung Chen; Shirazian, Shahrzad; Liang, Congxin; Vojkovsky, Tomas; Nematalla, Asaad S.; Hawley, Michael
Patent: US2002/156292 A1, 2002 ;

253870-02-92,4-二甲基-5-醛基-1H-吡咯-3-羧酸+

1374685-40-1

356068-93-45-((Z)-(5-氟-2-氧代吲哚烷-3-亚基)甲基)-2,4-二甲基-1H-吡咯-3-羧酸

参考文献

SCINOPHARM TAIWAN, LTD.; Henscheke, Julian P.; Chen, Yung-Fa
Patent: US2013/190512 A1, 2013 ;
Location in patent: Paragraph 0087 ;

110-89-4哌啶+

253870-02-92,4-二甲基-5-醛基-1H-吡咯-3-羧酸

356068-93-45-((Z)-(5-氟-2-氧代吲哚烷-3-亚基)甲基)-2,4-二甲基-1H-吡咯-3-羧酸

参考文献

SUGEN, INC.
Patent: US2004/209937 A1, 2004 ;

110-89-4哌啶+

253870-02-92,4-二甲基-5-醛基-1H-吡咯-3-羧酸

356068-93-45-((Z)-(5-氟-2-氧代吲哚烷-3-亚基)甲基)-2,4-二甲基-1H-吡咯-3-羧酸

参考文献

SUGEN, Inc.
Patent: US2003/130280 A1, 2003 ;
US 20030130280 A1

253870-02-92,4-二甲基-5-醛基-1H-吡咯-3-羧酸

356068-94-5托西尼布

参考文献

Sun, Li; Liang, Chris; Shirazian, Sheri; Zhou, Yong; Miller, Todd; Cui, Jean; Fukuda, Juri Y.; Chu, Ji-Yu; Nematalla, Asaad; Wang, Xueyan; Chen, Hui; Sistla, Anand; Luu, Tony C.; Tang, Flora; Wei, James; Tang, Cho
Journal of Medicinal Chemistry, 2003 , vol. 46, # 7 p. 1116 - 1119

253870-02-92,4-二甲基-5-醛基-1H-吡咯-3-羧酸

557795-19-4舒尼替尼

参考文献

Natco Pharma Limited
Patent: US2011/92717 A1, 2011 ;

253870-02-92,4-二甲基-5-醛基-1H-吡咯-3-羧酸+

100-36-7N,N-二乙基乙二胺

557795-19-4舒尼替尼

参考文献

SYNTHON B.V.; ZHU, Jie
Patent: WO2011/110199 A1, 2011 ;

253870-02-92,4-二甲基-5-醛基-1H-吡咯-3-羧酸

356068-86-5N-(2-(二乙基氨基)乙基)-5-甲酰基-2,4-二甲基-1H-吡咯-3-甲酰胺

参考文献

Sugen. Inc.
Patent: US2003/100555 A1, 2003 ;
US 20030100555 A1

253870-02-92,4-二甲基-5-醛基-1H-吡咯-3-羧酸+

100-36-7N,N-二乙基乙二胺

356068-86-5N-(2-(二乙基氨基)乙基)-5-甲酰基-2,4-二甲基-1H-吡咯-3-甲酰胺

参考文献

Zou, Hongbin; Zhang, Liang; Ouyang, Jingfeng; Giulianotti, Marc A.; Yu, Yongping
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 5970 - 5977