反应条件
1.1: tetrahydrofuran / 4 h / 20 °C 2.1: Na2S*9H2O; water / tetrahydrofuran; 1,4-dioxane / 2 h / 0 °C 3.1: dicyclohexyl-carbodiimide / tetrahydrofuran; dichloromethane / 6 h / 0 °C / Inert atmosphere 4.1: methylhydrazine / tetrahydrofuran / -80 °C / Inert atmosphere 4.2: 24 h / 20 °C 5.1: 25 °C / pH 10 / aq. buffer View Scheme
参考文献
Hemenway, Jeffrey N.; Jarho, Pekka; Henri, John T.; Nair, Sajiv K.; Vandervelde, David; Georg, Gunda I.; Stella, Valentino J.
Journal of Pharmaceutical Sciences, 2010 , vol. 99, # 4 p. 1810 - 1825