顺式-4-羟基-D-脯氨酸合成路线

114676-47-0顺式-4-羟基-D-脯氨酸甲酯

2584-71-6顺式-4-羟基-D-脯氨酸

参考文献

Tetrahedron Asymmetry, , vol. 7, # 3 p. 825 - 830

33996-33-7N-乙酰-L-4-羟基脯氨酸

2584-71-6顺式-4-羟基-D-脯氨酸

参考文献

Tetrahedron Asymmetry, , vol. 13, # 2 p. 197 - 201

46122-47-8(4R)-4-乙酰氧基-L-脯氨酸

2584-71-6顺式-4-羟基-D-脯氨酸+

51-35-4L-羟基脯氨酸

参考文献

Verheijen, Jeroen C.; Van Roon, Anne-Marie M.; Van Der Laan, Alexander C.; Van Der Marel, Gijsbert A.; Van Boom, Jacques H.
Nucleosides and Nucleotides, 1999 , vol. 18, # 3 p. 493 - 508

108-24-7乙酸酐+

64-19-7醋酸+

51-35-4L-羟基脯氨酸

2584-71-6顺式-4-羟基-D-脯氨酸

参考文献

Journal of Biological Chemistry, , vol. 195, p. 383,384

2584-71-6顺式-4-羟基-D-脯氨酸

141850-54-6(2R,4R)-叔丁基 4-羟基-2-(羟基甲基)吡咯烷-1-羧酸

参考文献

Nakamura, Takako; Matsuyama, Haruo; Kamigata, Nobumasa; Iyoda, Masahiko
Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3783 - 3789

501-53-1氯甲酸苄酯+

2584-71-6顺式-4-羟基-D-脯氨酸

130930-25-5顺式-N-cbz-L-羟脯氨酸

参考文献

GENENTECH, INC.
Patent: WO2008/24725 A1, 2008 ;
Location in patent: Page/Page column 126 ;
WO 2008/024725 A1

64-17-5乙醇+

2584-71-6顺式-4-羟基-D-脯氨酸

132666-67-22-(R)-乙氧羰基-4-(R)-羟基吡咯烷

参考文献

Renau, Thomas E.; Leger, Roger; Filonova, Lubov; Flamme, Eric M.; Wang, Michael; Yen, Rose; Madsen, Deidre; Griffith, David; Chamberland, Suzanne; Dudley, Michael N.; Lee, Ving J.; Lomovskaya, Olga; Watkins, William J.; Ohta, Toshiharu; Nakayama, Kiyoshi; Ishida, Yohei
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 16 p. 2755 - 2758

67-56-1甲醇+

2584-71-6顺式-4-羟基-D-脯氨酸

114676-59-4(4R)-4-羟基-D-脯氨酸甲酯盐酸盐

参考文献

VICURON PHARMACEUTICALS, INC.
Patent: WO2004/7444 A2, 2004 ;
Location in patent: Page 135 ;

2584-71-6顺式-4-羟基-D-脯氨酸

114676-59-4(4R)-4-羟基-D-脯氨酸甲酯盐酸盐

参考文献

Shionogi Seiyaku Kabushiki Kaisha
Patent: US5317016 A1, 1994 ;

75-36-5乙酰氯+

2584-71-6顺式-4-羟基-D-脯氨酸

114676-59-4(4R)-4-羟基-D-脯氨酸甲酯盐酸盐