1-(4-甲基苯基)-3-苯基-1,3-丙烷二酮合成路线 （共 37 条）
反应条件
potassium tert-butylate in tert-butyl alcohol
T=20°C; 3 h; Inert atmosphere;
参考文献
Nakaiida, Shoho; Kato, Shinzi; Niyomura, Osamu; Ishida, Masaru; Ando, Fumio; Koketsu, Jugo
Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 5-6 p. 930 - 946
反应条件
hydrogenchloride in N,N-dimethyl-formamide
4 h; Ambient temperature;
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
反应条件
hydrogenchloride; bromine; sodium methylate
1.) CHCl3, ice water bath, then 30 min, room t., 2.) MeOH, reflux, 1 h, 3.) MeOH, reflux, 15 min; Multistep reaction;
参考文献
Davis, Brian R.; Hinds, Mark G.
Australian Journal of Chemistry, 1997 , vol. 50, # 4 p. 309 - 319
反应条件
sodium hydroxide in dimethyl sulfoxide
参考文献
Wallet, Jean-Claude; Gaydou, Emile M.
Synthetic Communications, 1996 , vol. 26, # 22 p. 4097 - 4103
参考文献
Merck Patent Gesellschaft mit beschraenkter Haftung
Patent: US4489057 A1, 1984 ;
反应条件
sodium methylate in methanol
参考文献
Dayer,F. et al.
Helvetica Chimica Acta, 1974 , vol. 57, # 7 p. 2201 - 2209
反应条件
1: methanol / 2 h / Heating
2: aq. HCl / methanol / 24 h / 0 °C
View Scheme
参考文献
Robert; Hassanine; Harraga; Seilles
Annales Pharmaceutiques Francaises, 1995 , vol. 53, # 6 p. 261 - 271
反应条件
1: 89 percent / ethanol / Heating
2: 75 percent / dilute HCl / methanol / 2 h / 60 - 65 °C
View Scheme
参考文献
Zanina, A. S.; Shergina, S. I.; Sokolov, I. E.; Myasnikova, R. N.
Russian Chemical Bulletin, 1995 , vol. 44, # 4 p. 689 - 694
Izvestiya Akademi Nauk, Seriya Khimicheskaya, 1995 , # 4 p. 710 - 714
反应条件
1: tetrahydrofuran
2: 74 percent / 2.) dil. HCl / dimethylformamide / 4 h / Ambient temperature
View Scheme
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
反应条件
1: 83 percent / 1.) 1N NaOH, 2.) cc. HCl / H2O / Ambient temperature
2: tetrahydrofuran
3: 74 percent / 2.) dil. HCl / dimethylformamide / 4 h / Ambient temperature
View Scheme
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
