4-羟基-2-三氟甲基喹唑啉合成路线 （共 12 条）
反应条件
1: 2-amino-benzamide With sodium ethanolate in ethanol T=60°C; 1 h; 2: ethyl-α,α,α-trifluoroacetate in ethanol T=60°C; 20 h;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2007/65940 A1, 2007 ;
Location in patent: Page/Page column 32 ;
反应条件
1: anthranilic acid; trifluoroacetic anhydride With pyridine in acetonitrile T=0 - 20°C; 2 h; 2: With (NH4)2CO3 T=0 - 20°C; 16 - 18 h; 3: acetic acid T=120°C; 3 h;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2006/71958 A1, 2006 ;
Location in patent: Page/Page column 133 ;
WO 2006/071958 A1
反应条件
ammonia in ethanol 2 h;
参考文献
Atkinson, Robert S.; Coogan, Michael P.; Cornell, Clive L.
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 2 p. 157 - 166
反应条件
sodium hydroxide; dihydrogen peroxide in 1,4-dioxane; water; ethyl acetate 12 h; Heating;
参考文献
Greiner, Jacques; Pastor, Raphael; Cambon, Aime
Journal of Fluorine Chemistry, 1981 , vol. 18, p. 185 - 196
反应条件
in methanol 9 h; Irradiation;
参考文献
Kaneko, Chikara; Kasai, Kouichi; Katagiri, Nobuya; Chiba, Takuo
Chemical & Pharmaceutical Bulletin, 1986 , vol. 34, # 9 p. 3672 - 3681
反应条件
pyrene in methanol 5 h; Irradiation; Product distribution; Further Variations:ReagentsSolventsreaction times, wavelengths;
参考文献
Buscemi, Silvestre; Pace, Andrea; Piccionello, Antonio Palumbo; Pibiri, Ivana; Vivona, Nicolo
Heterocycles, 2004 , vol. 63, # 7 p. 1619 - 1628
反应条件
in acetic acid 2 h; Heating; Yield given;
参考文献
Bergman, Jan; Bergman, Solveig
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1246 - 1255
参考文献
Kaneko, Chikara; Kasai, Kouichi; Katagiri, Nobuya; Chiba, Takuo
Chemical & Pharmaceutical Bulletin, 1986 , vol. 34, # 9 p. 3672 - 3681
反应条件
0.05 h; microwave irradiation;
参考文献
Rahimizadeh; Tavallai; Bakavoli
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 3 p. 679 - 681
反应条件
1: dioxane / 1 h / 25 °C 2: acetic acid / 2 h / Heating View Scheme
参考文献
Bergman, Jan; Bergman, Solveig
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1246 - 1255
