2-苄基丙烷-1,3-二醇合成路线 （共 23 条）
反应条件
dimethyl sulfoxide T=190°C; 24 h;
参考文献
Brink, M.; Schjanberg, E.
Journal fuer Praktische Chemie (Leipzig), 1981 , vol. 323, # 5 p. 836 - 838
反应条件
1: 65 percent / Ph3P, Br2 / CH2Cl2 / 2 h / 0 °C 2: 20 percent / NaBH4 / ethanol / 1) 0 deg C, 30 min, 2) reflux, 48 h 3: Ph3SnH, AIBN / benzene / 80 °C View Scheme
参考文献
Tetrahedron, , vol. 55, # 11 p. 3327 - 3336
反应条件
1: Et3N / CH2Cl2 / 1) 0 deg C to room temperature, 2) room temperature, overnight 2: NaI / acetone / 48 h / Heating 3: Ph3SnH, AIBN / benzene / 80 °C View Scheme
参考文献
Colonge,J.; Robert,H.
Bulletin de la Societe Chimique de France, 1960 , p. 736 - 740
反应条件
1.1: 94 percent / lipase PS-30 (Amano) / tetrahydrofuran / 2 h / 20 °C 2.1: HN3; diethyl azodicarboxylate; PPh3 / benzene; tetrahydrofuran / -35 - 20 °C 2.2: H2 / Pd-C / ethyl acetate / 20 °C 3.1: 62 percent / K2CO3; H2O / methanol / 2 h / 20 °C 4.1: Jones reagent / acetone / 1 h / 20 °C View Scheme
参考文献
Khumtaveeporn, Kanjai; Ullmann, Astrid; Matsumoto, Kazutsugu; Davis, Benjamin G.; Jones
Tetrahedron Asymmetry, 2001 , vol. 12, # 2 p. 249 - 261
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Lu, Ding; Sham, Yuk Yin; Vince, Robert
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 5 p. 2037 - 2048
反应条件
lithium aluminium tetrahydride in diethyl ether
Ambient temperature;
参考文献
Jenmalm, Annika; Berts, Wei; Li, Yi-Lin; Luthman, Kristina; Csoeregh, Ingeborg; Hacksell, Uli
Journal of Organic Chemistry, 1994 , vol. 59, # 5 p. 1139 - 1148
反应条件
sodium tetrahydroborate; CoCl2.6H2O; diisopropylamine in ethanol
T=50°C; 24 h; chemoselective reaction;
参考文献
Jagdale, Arun R.; Paraskar, Abhimanyu S.; Sudalai, Arumugam
Synthesis, 2009 , # 4 p. 660 - 664
反应条件
1: With L-proline in N,N-dimethyl-formamide
T=20°C;
2: With sodium tetrahydroborate in methanol
T=0°C; Further stages.;
参考文献
Casas, Jesus; Sunden, Henrik; Cordova, Armando
Tetrahedron Letters, 2004 , vol. 45, # 32 p. 6117 - 6119
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 25°C; 3 h;
参考文献
Ramachary, Dhevalapally B.; Venkaiah, Chintalapudi; Reddy, Y. Vijayendar; Kishor, Mamillapalli
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 10 p. 2053 - 2062
反应条件
sodium hydroxide in tetrahydrofuran; water; Petroleum ether
参考文献
Societe Civile Bioprojet
Patent: US6013829 A1, 2000 ;
US 6013829 A
