(2-甲基-1H-吲哚-3-基)(苯基)甲酮合成路线 （共 30 条）
反应条件
1: 1.) BH3*SMe2, 2.) CH3OH / 1.) THF, 0 deg C, 2 h; r.t., 2 h, 2.) THF, 1 h, reflux 2: 80 percent / O3/O2 / ethyl acetate / 14 h 3: 67 percent / 5M HCl / ethanol / 3 h / Heating 4: 1.) NaNO2, 10M HCl, 2.) NaN3 / 1.) H2O, 0 deg C, 30 min, 2.) H2O, 10 min 5: 75 percent / NH2NH2*H2O, CH3COOH / ethanol / 15 h / Heating View Scheme
参考文献
Clark, Brian J.; Grayshan, Roger
Journal of Chemical Research, Miniprint, 1981 , # 10 p. 3786 - 3795
反应条件
toluene-4-sulfonic acid in benzene 6 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 29, # 6 p. 1371 - 1373
反应条件
1-n-butyl-3-methylimidazolium hexafluorophosphate; zinc oxide
T=15°C; Friedel-Crafts Acylation; 3 h; Inert atmosphere;
参考文献
Zhang, Li-Rong; Yi, Feng-Ping; Zou, Jian-Zhong; Zhang, Xuan; Wang, Zhen
2012 , vol. 36, # 10 p. 600 - 602,3
反应条件
triethylamine; tris-(o-tolyl)phosphine; palladium diacetate in N,N-dimethyl-formamide
T=120°C;
参考文献
Sakamoto, Takao; Nagano, Tatsuo; Kondo, Yoshinori; Yamanaka, Hiroshi
Synthesis, 1990 , # 3 p. 215 - 218
反应条件
triethylamine; palladium diacetate in N,N-dimethyl-formamide
T=120°C; 4 h;
参考文献
Sakamoto, Takao; Nagano, Tatsuo; Kondo, Yoshinori; Yamanaka, Hiroshi
Synthesis, 1990 , # 3 p. 215 - 218
反应条件
iron; acetic acid
T=120°C; chemoselective reaction;
参考文献
Coffman, Keith C.; Palazzo, Teresa A.; Hartley, Timothy P.; Fettinger, James C.; Tantillo, Dean J.; Kurth, Mark J.
Organic Letters, 2013 , vol. 15, # 8 p. 2062 - 2065
反应条件
copper(l) iodide; caesium carbonate; 1,1'-binaphthyl-2,2'-diol in dimethyl sulfoxide
T=50°C; 4 h;
参考文献
Tanimori, Shinji; Inaba, Ushio; Kato, Yoshihiro; Ura, Haruna; Kashiwagi, Hiroaki; Nishimura, Takeshi; Kirihata, Mitsunori
Research on Chemical Intermediates, 2014 , vol. 40, # 6 p. 2157 - 2164
反应条件
copper (II) acetate monohydrate; silver carbonate in dimethyl sulfoxide
T=90°C;
参考文献
Wang, Cuiping; Wang, Shaoyan; Li, Hua; Yan, Jingbo; Chi, Haijun; Chen, Xichao; Zhang, Zhiqiang
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 11 p. 1721 - 1724
反应条件
boron trifluoride diethyl etherate in dichloromethane
参考文献
Akguen, E.; Pindur, U.; Mueller, J.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1303 - 1305
反应条件
1: 69 percent / TsOH / benzene / Heating
2: 36 percent / Et3N, P(2-CH3C6H4)3 / Pd(OAc)2 / dimethylformamide / 120 °C
View Scheme
参考文献
Sakamoto, Takao; Nagano, Tatsuo; Kondo, Yoshinori; Yamanaka, Hiroshi
Synthesis, 1990 , # 3 p. 215 - 218
