反应条件
1: 69 percent / ammonium hydroxide / 168 h / Ambient temperature
2: 68 percent / aq. NaOH / 3 h / 10 °C
3: 65 percent / dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) room temperature, 17.0 h
4: 1.) 1-hydroxybenzotriale, N-methylmorpholine, 2.) hydrogen / 1.) palladium black / 1.) DMF, water, room temperature, 20 h, 2.) DMF. methanol, 1.0 h
View Scheme
参考文献
Khare; Becker; Naider
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 650 - 656
