2,4,6-三氟苯基丙二酸二乙酯合成路线 （共 7 条）
反应条件
hydrogen; triethylamine; nickel in tetrahydrofuran T=24°C; 2.25 h;
参考文献
US2009/131708 A1, ;
Page/Page column 3 ;
反应条件
1: diethyl malonate With sodium methylate T=20 - 60°C; Industry scale; 2: 1-bromo-2,4,6-trifluoro-benzene With copper(I) bromide in ethanol T=75 - 100°C; P=760.051 Torr; 12.3333 h; Industry scale; Product distribution / selectivity;
参考文献
US2010/56820 A1, ;
Page/Page column 4 ;
反应条件
1: 3,3-dichloro-2-(2,4,6-trifluoro-phenyl)-acrylicacidethylester; sodium ethanolate in ethanol T=0°C; 1.66667 h; 2: acetic acid in ethanol; water T=10°C; 2 h;
参考文献
US2008/200675 A1, ;
Page/Page column 4 ;
反应条件
hydrogenchloride; copper monobromide
反应条件
1: anhydrous iron chloride; bromine 2: sodium ethanolate; copper(I) bromide View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 32 p. 4117 - 4120
反应条件
1.1: tributyl-amine / 2 h / 170 °C
1.2: 50 °C
2.1: trichlorophosphate / 6 h / 130 °C
View Scheme
参考文献
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; BALLATORE, Carlo; BRUNDEN, Kurt, R.; HOYE, Adam, T.; LEE, Virginia, M.y.; SMITH, Amos, B.; TROJANOWSKI, John, Q.
Patent: WO2014/47257 A2, 2014 ;
反应条件
tributyl-amine
T=180°C; 1 h; Inert atmosphere;
参考文献
Zhang, Nan; Ayral-Kaloustian, Semiramis; Nguyen, Thai; Hernandez, Richard; Lucas, Judy; Discafani, Carolyn; Beyer, Carl
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 111 - 118
