(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
magnesium in tetrahydrofuran; methanol T=0°C; 2 h;
参考文献
Nakamura, Shuichi; Nakashima, Hiroki; Sugimoto, Hideki; Sano, Hideaki; Hattori, Masataka; Shibata, Norio; Toru, Takeshi
Chemistry - A European Journal, 2008 , vol. 14, # 7 p. 2145 - 2152
反应条件
Candida antarctica lipase B immobilized on acrylic resin in toluene T=25°C; 0.0666667 h; Resolution of racemateFlow reactor; TemperatureTimeReagent/catalyst;
参考文献
De Miranda, Amanda S.; Miranda, Leandro S. M.; De Souza, Rodrigo O. M. A.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 20 p. 3332 - 3336
反应条件
(2S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol-borane in tetrahydrofuran T=30°C; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Itsuno, Shinichi; Nakano, Michio; Miyazaki, Koji; Masuda, Hirofumi; Ito, Koichi; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2039 - 2044
反应条件
(2S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol-borane in tetrahydrofuran T=30°C; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Itsuno, Shinichi; Nakano, Michio; Miyazaki, Koji; Masuda, Hirofumi; Ito, Koichi; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2039 - 2044
反应条件
L-ERYTHRO-(1R,2S)-2-AMINO-1-PHENYLPROPAN-1-OL; borane in tetrahydrofuran T=0°C; 24 h;
参考文献
Krzeminski, Marek P.; Zaidlewicz, Marek
Tetrahedron Asymmetry, 2003 , vol. 14, # 11 p. 1463 - 1466
反应条件
1: toluene; diethyl ether / 0.42 h / -20 °C 2: 80 percent / Mo(CO)6 / acetonitrile; H2O / 1 h / 85 °C View Scheme
参考文献
Atobe, Masakazu; Yamazaki, Naoki; Kibayashi, Chihiro
Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5595 - 5607
反应条件
1: 99 percent / TsOH / toluene / 0.5 h / Heating 2: toluene; diethyl ether / 0.42 h / -20 °C 3: 80 percent / Mo(CO)6 / acetonitrile; H2O / 1 h / 85 °C View Scheme
参考文献
Yang, Teng-Kuei; Chen, Ruey-Yuan; Lee, Dong-Sheng; Peng, Wen-Shiuan; Jiang, Yao-Zhong; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 4 p. 914 - 921
反应条件
1: (1S,3R,4R)-2-benzyl-3-(2-hydroxy-2-propyl)-2-azabicyclo<2.2.1>heptane / toluene; hexane / 0 - 20 °C 2: 1.) HCl, 2.) NaOH / 1.) methanol, room temperature View Scheme
参考文献
Guijarro, David; Pinho, Pedro; Andersson, Pher G.
Journal of Organic Chemistry, 1998 , vol. 63, # 8 p. 2530 - 2535
反应条件
1: 82 percent / 85percent m-chloroperoxybenzoic acid / tetrahydrofuran / 0.17 h / -78 °C 2: tetrahydrofuran; diethyl ether / 0.5 h 3: 1.) TiCl4, Zn, 2.) 6 N aq. HCl / 1.) CH2Cl2, ether, r.t., 10 min, 2.) 3 h View Scheme
参考文献
Yang, Teng-Kuei; Chen, Ruey-Yuan; Lee, Dong-Sheng; Peng, Wen-Shiuan; Jiang, Yao-Zhong; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 4 p. 914 - 921
反应条件
1: tetrahydrofuran; diethyl ether / 0.5 h 2: 1.) TiCl4, Zn, 2.) 6 N aq. HCl / 1.) CH2Cl2, ether, r.t., 10 min, 2.) 3 h View Scheme
参考文献
Yang, Teng-Kuei; Chen, Ruey-Yuan; Lee, Dong-Sheng; Peng, Wen-Shiuan; Jiang, Yao-Zhong; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 4 p. 914 - 921
