(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
1: diisobutylaluminum hydride / tetrahydrofuran / 1 h / -30 °C 2: 92 percent / CF3COOH / methanol / 3 h / 25 °C View Scheme
参考文献
Hua, Duy H.; Miao, Shou Wu; Chen, Jin Shan; Iguchi, Sadahiko
Journal of Organic Chemistry, 1991 , vol. 56, # 1 p. 4 - 6
反应条件
1: 1.) ether, 0 deg C, 1 h 2.) 0 deg C 2: diisobutylaluminum hydride / tetrahydrofuran / 1 h / -30 °C 3: 92 percent / CF3COOH / methanol / 3 h / 25 °C View Scheme
参考文献
Annunziata, Rita; Cinquini, Mauro; Cozzi, Franco
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 339 - 344
反应条件
1: 97 percent / pyridine, DMAP / CH2Cl2 / 0.5 h / Heating 2: 53 percent / Li/NH3 / tetrahydrofuran / 0.02 h / -33 °C 3: 1) H5IO6, MeNH2, 2) 4N HCl / 1) aq. MeOH, RT, 3h, 2) ether, 30 min View Scheme
参考文献
Chang, Zen-Yu; Coates, Robert M.
Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3475 - 3483
反应条件
1: 92 percent / diethyl ether / 0.5 h / 25 °C 2: 97 percent / pyridine, DMAP / CH2Cl2 / 0.5 h / Heating 3: 53 percent / Li/NH3 / tetrahydrofuran / 0.02 h / -33 °C 4: 1) H5IO6, MeNH2, 2) 4N HCl / 1) aq. MeOH, RT, 3h, 2) ether, 30 min View Scheme
参考文献
Chang, Zen-Yu; Coates, Robert M.
Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3475 - 3483
反应条件
1: 53 percent / Li/NH3 / tetrahydrofuran / 0.02 h / -33 °C 2: 1) H5IO6, MeNH2, 2) 4N HCl / 1) aq. MeOH, RT, 3h, 2) ether, 30 min View Scheme
参考文献
Chang, Zen-Yu; Coates, Robert M.
Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3475 - 3483
反应条件
alanine dehydrogenase; (S)-α-alanine; pyridoxal 5'-phosphate; nicotinamide adenine dinucleotide; ammonium chloride; alcohol dehydrogenase in aq. phosphate buffer T=30°C; 24 h; Enzymatic reaction;
参考文献
Tauber, Katharina; Fuchs, Michael; Sattler, Johann H.; Pitzer, Julia; Pressnitz, Desiree; Koszelewski, Dominik; Faber, Kurt; Pfeffer, Jan; Haas, Thomas; Kroutil, Wolfgang
Chemistry - A European Journal, 2013 , vol. 19, # 12 p. 4030 - 4035
反应条件
L-ERYTHRO-(1R,2S)-2-AMINO-1-PHENYLPROPAN-1-OL; diborane Inert atmosphere;
参考文献
Laczkowski, Krzysztof Z.
Acta Poloniae Pharmaceutica - Drug Research, 2013 , vol. 70, # 2 p. 237 - 244
反应条件
Candida antarctica lipase B immobilized on acrylic resin in toluene T=25°C; 0.0666667 h; Resolution of racemateFlow reactor; TemperatureTime;
参考文献
De Miranda, Amanda S.; Miranda, Leandro S. M.; De Souza, Rodrigo O. M. A.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 20 p. 3332 - 3336
反应条件
in dichloromethane T=5°C; Acylation; Kinetic resolution; Title compound not separated from byproducts;
参考文献
Al-Sehemi, Abdullah G.; Atkinson, Robert S.; Fawcett, John; Russell, David R.
Chemical Communications, 2000 , # 1 p. 43 - 44
反应条件
1: With {RuCl2(1-methyl-4-(1-methylethyl)benzene)}2; ethanolamine; potassium hydroxide in isopropyl alcohol T=25°C; 15 h; 2: With hydrogenchloride in methanol optical yield given as percent eestereoselective reaction;
参考文献
Guijarro, David; Pablo, Oscar; Yus, Miguel
Tetrahedron Letters, 2009 , vol. 50, # 38 p. 5386 - 5388
