(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
1: sodium ethoxide / ethanol / 1 h / 40 °C 2: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
参考文献
Ikota; Achiwa; Yamada
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 887 - 894
反应条件
1: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C 2: sodium ethoxide / ethanol / 1 h / 40 °C 3: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
参考文献
Ikota; Achiwa; Yamada
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 887 - 894
反应条件
hydroxylammonium acetate T=40°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Yaozhong, Jiang; Peng, Guo; Guilan, Liu
Synthetic Communications, 1990 , vol. 20, # 1 p. 15 - 22
反应条件
water; hydroxide Title compound not separated from byproducts;
参考文献
Chapman, Daniel T.; Crout, David H. G.; Mahmoudian, Mahmoud; Scopes, David I. C.; Smith, Paul W.
Chemical Communications, 1996 , # 21 p. 2415 - 2416
反应条件
N,N'-dimethyl-N,N'-propyleneurea T=-20°C; 24 h; Title compound not separated from byproducts;
参考文献
Sabot, Cyrille; Subhash, Pithani V.; Valleix, Alain; Arseniyadis, Stellios; Mioskowski, Charles
Synlett, 2008 , # 2 p. 268 - 272
反应条件
1: LiAlH4 / diethyl ether / 15 h / 25 °C / other reagent,other solvent 2: trifluoroacetic acid / methanol / 1 h / 0 °C View Scheme
参考文献
Annunziata, Rita; Cinquini, Mauro; Cozzi, Franco
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 339 - 344
反应条件
1: 1) butyllithium / 1) THF, -70 deg C, hexane, 10 min, 2) THF, room temperature, 48 h 2: 50percent NaOH, benzyltriethylammoniumchloride / CH2Cl2 / 2 h / Ambient temperature 3: 1) gaseous HCl, 2) HCl / methanol; H2O / 1) 24 h, reflux, 2) 24 h, reflux View Scheme
参考文献
Schoellkopf, Ulrich; Hausberg, Hans-Heinrich; Segal, Marcos; Reiter, Udo; Hoppe, Inga; et al.
Liebigs Annalen der Chemie, 1981 , # 3 p. 439 - 458
反应条件
1: 38.5 percent / 1) 2 h, 85 deg C, 2) 1 h, 120 deg C 2: 50percent NaOH, benzyltriethylammoniumchloride / CH2Cl2 / 2 h / Ambient temperature 3: 1) gaseous HCl, 2) HCl / methanol; H2O / 1) 24 h, reflux, 2) 24 h, reflux View Scheme
参考文献
Schoellkopf, Ulrich; Hausberg, Hans-Heinrich; Segal, Marcos; Reiter, Udo; Hoppe, Inga; et al.
Liebigs Annalen der Chemie, 1981 , # 3 p. 439 - 458
反应条件
1: 50percent NaOH, benzyltriethylammoniumchloride / CH2Cl2 / 2 h / Ambient temperature 2: 1) gaseous HCl, 2) HCl / methanol; H2O / 1) 24 h, reflux, 2) 24 h, reflux View Scheme
参考文献
Schoellkopf, Ulrich; Hausberg, Hans-Heinrich; Segal, Marcos; Reiter, Udo; Hoppe, Inga; et al.
Liebigs Annalen der Chemie, 1981 , # 3 p. 439 - 458
反应条件
Candida antarctica lipase B (CAL-B) immobilized on resin EXE 120 in tert-butyl methyl ether 18 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Truppo, Matthew D.; Hughes, Gregory
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1033 - 1035
