(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
1: (S)-N-acetyl-1-phenylethylamine With triphenyl phosphite; chlorine; triethylamine in dichloromethane T=-30°C; 2: ethylene glycol in dichloromethane T=-30 - 20°C; 3: With water
参考文献
Spaggiari, Alberto; Blaszczak, Larry C.; Prati, Fabio
Organic Letters, 2004 , vol. 6, # 22 p. 3885 - 3888
反应条件
hexacarbonyl molybdenum in water; acetonitrile T=85°C; 1 h;
参考文献
Atobe, Masakazu; Yamazaki, Naoki; Kibayashi, Chihiro
Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5595 - 5607
反应条件
Novozym 435 in toluene T=23°C; 6 h; Molecular sieveEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Paeivioe, Mari; Perkioe, Paeivi; Kanerva, Liisa T.
Tetrahedron Asymmetry, 2012 , vol. 23, # 3-4 p. 230 - 236
反应条件
Novozym 435 in toluene T=23°C; 6 h; Molecular sieveEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Paeivioe, Mari; Perkioe, Paeivi; Kanerva, Liisa T.
Tetrahedron Asymmetry, 2012 , vol. 23, # 3-4 p. 230 - 236
反应条件
Candida antarctica lipase in di-isopropyl ether T=30°C; 120 h;
参考文献
Torre, Oliver; Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 8-9 p. 1481 - 1488
反应条件
dimethylsulfide borane complex; 1-[([1,3,2]dioxaborolan-2-yloxy)-diphenyl-methyl]-2-methylpropylamine in tetrahydrofuran T=20°C; 36 - 48 h; Product distribution / selectivity;
参考文献
OFFICE OF INTELLECTUAL PROPERTY AND TECHNOLOGY
Patent: WO2008/27740 A2, 2008 ;
Location in patent: Page/Page column 7-9 ;
反应条件
heptakis-(6-O-TIPS)-β-CD; triethylamine in cyclohexane T=10°C; 12 h; Resolution of racemate;
参考文献
Asahara, Haruyasu; Kida, Toshiyuki; Iwamoto, Takuya; Hinoue, Tomoaki; Akashi, Mitsuru
Tetrahedron, 2014 , vol. 70, # 2 p. 197 - 203
反应条件
sodium 2-oxopropanoate T=30°C; 24 h; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Koszelewski, Dominik; Mueller, Nicole; Schrittwieser, Joerg H.; Faber, Kurt; Kroutil, Wolfgang
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 63, # 1-2 p. 39 - 44
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol T=45°C; P=4045.3 Torr; 12 h; Yield given. Yields of byproduct given;
参考文献
Takahashi; Tomita; Noguchi
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 11 p. 3387 - 3391
反应条件
Candida antarctica lipase B in n-heptane T=80°C; 4 h;
参考文献
Irimescu, Roxana; Kato, Katsuya
Tetrahedron Letters, 2004 , vol. 45, # 3 p. 523 - 525
