(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
potassium hydroxide; Alcaligenes faecalis penicillin acylase in water T=25°C; pH=10; 0.283333 h;
参考文献
Guranda, Dorel T.; Khimiuk, Andrey I.; Van Langen, Luuk M.; Van Rantwijk, Fred; Sheldon, Roger A.; Svedas, Vytas K.
Tetrahedron Asymmetry, 2004 , vol. 15, # 18 p. 2901 - 2906
反应条件
1: diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; (S)-3,3'-bis(2,4,6-iPr3-phenyl)-BINOL cyclic phosphate / toluene / 45 h / 35 °C 2: CAN; H2O / methanol / 0 °C View Scheme
参考文献
Hoffmann, Sebastian; Seayad, Abdul Majeed; List, Benjamin
Angewandte Chemie - International Edition, 2005 , vol. 44, # 45 p. 7424 - 7427
反应条件
novozyme 435 in ethylene glycol dimethyl ether T=40°C; 19 h; Molecular sieveEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
De Miranda, Amanda S.; Miranda, Leandro S. M.; De Souza, Rodrigo O. M. A.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 20 p. 3332 - 3336
反应条件
transaminase ATA-117; pyridoxal 5'-phosphate; sodium 2-oxopropanoate T=30°C; pH=7.0; 24 h; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
Koszelewski, Dominik; Clay, Dorina; Rozzell, David; Kroutil, Wolfgang
European Journal of Organic Chemistry, 2009 , # 14 p. 2289 - 2292
反应条件
thionyl chloride beim Behandeln des hergestellten Saeurechlorids mit Natriumazid in Aether und Erwaermen des Reaktionsprodukts mit wss.Salzsaeure;
参考文献
Campbell; Kenyon
Journal of the Chemical Society, 1946 , p. 25
反应条件
citric acid in diethyl ether 2.5 h;
参考文献
Noe, Christian R.
Chemische Berichte, 1982 , vol. 115, # 4 p. 1591 - 1606
反应条件
Novozym 435 in toluene T=30°C; 72 h; Enzymatic reactionkinetic resolution;
参考文献
Roengpithya, Chayaporn; Patterson, Darrell A.; Livingston, Andrew G.; Taylor, Paul C.; Irwin, Jacob L.; Parrett, Mark R.
Chemical Communications, 2007 , # 33 p. 3462 - 3463
反应条件
hydrogenchloride in methanol T=25°C; 3 h;
参考文献
Guijarro, David; Pinho, Pedro; Andersson, Pher G.
Journal of Organic Chemistry, 1998 , vol. 63, # 8 p. 2530 - 2535
反应条件
Candida antarctica lipase in di-isopropyl ether T=30°C; 120 h;
参考文献
Yang, Bo; Zhang, Yanjun; Zhang, Shusheng; Izumi
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 6 p. 1312 - 1316
反应条件
novozyme 435 in ethylene glycol dimethyl ether T=40°C; 48 h; Molecular sieveEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Ismail, Hilda; Lau, Rute Madeira; Van Rantwijk, Fred; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 10 p. 1511 - 1516
