(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
1: p-toluenesulfonic acid / toluene / Heating 2: H2 / Raney-nickel W2 / ethanol / 24 h / 3750.3 Torr / Ambient temperature 3: HCO2NH4 / 10percent Pd/C / methanol / 0.5 h / Heating View Scheme
参考文献
Bringmann, G.; Geisler, J.-P.
Journal of Fluorine Chemistry, 1990 , vol. 49, # 1 p. 67 - 73
反应条件
1: H2 / Raney-nickel W2 / ethanol / 24 h / 3750.3 Torr / Ambient temperature 2: HCO2NH4 / 10percent Pd/C / methanol / 0.5 h / Heating View Scheme
参考文献
Bringmann, G.; Geisler, J.-P.
Journal of Fluorine Chemistry, 1990 , vol. 49, # 1 p. 67 - 73
反应条件
1-n-butyl-3-methylimidazolium hexafluorophosphate in n-heptane T=35°C; Resolution of racemateMicrobiological reaction;
参考文献
De Miranda, Amanda S.; Miranda, Leandro S. M.; De Souza, Rodrigo O. M. A.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 20 p. 3332 - 3336
反应条件
Candida antarctica lipase B immobilized on acrylic resin in toluene T=25°C; 0.666667 h; Resolution of racemateFlow reactor;
参考文献
De Miranda, Amanda S.; Miranda, Leandro S. M.; De Souza, Rodrigo O. M. A.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 20 p. 3332 - 3336
反应条件
(2S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol-borane in tetrahydrofuran T=30°C; 24 h; Yield given;
参考文献
Itsuno, Shinichi; Nakano, Michio; Miyazaki, Koji; Masuda, Hirofumi; Ito, Koichi; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2039 - 2044
反应条件
dimethylsulfide borane complex; (S)-(-)-2-amino-1,1,2-triphenylethanol in dichloromethane T=-10°C; 15 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ortiz-Marciales, Margarita; Tirado, Liz M.; Colon, Roberto; Ufret, Maria L.; Figueroa, Ruth; Lebron, Marisabel; DeJesus, Melvin; Martinez, Johanna; Malave, Tania
Synthetic Communications, 1998 , vol. 28, # 21 p. 4067 - 4075
反应条件
Candida antarctica (Novozym 435) T=21°C; 504 h; Enzymatic reaction;
参考文献
Davis; Durden
Synthetic Communications, 2001 , vol. 31, # 4 p. 569 - 578
反应条件
1: With sodium tetrahydridoaluminate; (-)-(R,R)-TADDOL in tetrahydrofuran T=-70°C; 2: With hydrogenchloride in methanol T=20°C; 3 h; Title compound not separated from byproducts;
参考文献
Vinogradov; Gorshkova; Chel'tsova; Pavlov; Razmanov; Ferapontov; Malyshev; Heise
Russian Chemical Bulletin, 2003 , vol. 52, # 2 p. 471 - 479
反应条件
1: 1) p-TsOH, 2) H2, Raney nickel / 1) toluene, reflux, 2) EtOH, 5 bar, RT, 24h 2: 62 percent / H2, ammonium formate / 10percent Pd-C / methanol / Heating View Scheme
参考文献
Bringmann, Gerhard; Geisler, Joerg-Peter; Geuder, Torsten; Kuenkel, Georg; Kinzinger Lioba
Liebigs Annalen der Chemie, 1990 , # 8 p. 795 - 805
反应条件
1: 60 percent / K2CO3 / acetone 2: 1) p-TsOH, 2) H2, Raney nickel / 1) toluene, reflux, 2) EtOH, 5 bar, RT, 24h 3: 62 percent / H2, ammonium formate / 10percent Pd-C / methanol / Heating View Scheme
参考文献
Bringmann, Gerhard; Geisler, Joerg-Peter; Geuder, Torsten; Kuenkel, Georg; Kinzinger Lioba
Liebigs Annalen der Chemie, 1990 , # 8 p. 795 - 805
