2-甲基-2-丙基3-(2-氯苯基)-3-氧代丙酸酯合成路线 （共 6 条）
反应条件
in toluene T=80 - 85°C; 4.5 h;
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Patent: WO2005/108347 A2, 2005 ;
Location in patent: Page/Page column 29 ;
WO 2005/108347 A2
反应条件
1: 4-(dimethylamino)pyridine / CH2Cl2 / -10 - 20 °C 2: 5 h / Heating View Scheme
参考文献
Hogenkamp, Derk J.; Johnstone, Timothy B. C.; Huang, Jin-Cheng; Li, Wen-Yen; Tran, Minhtam; Whittemore, Edward R.; Bagnera, Rudy E.; Gee, Kelvin W.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3369 - 3379
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere 1.2: 3 h / -78 °C 2.1: manganese(IV) oxide / dichloromethane / |Reflux View Scheme
参考文献
Loy, Nicole S. Y.; Singh, Alok; Xu, Xianxiu; Park, Cheol-Min
Angewandte Chemie - International Edition, 2013 , vol. 52, # 8 p. 2212 - 2216
Angew. Chem., vol. 125, # 8 p. 2268 - 2272,5
反应条件
manganese(IV) oxide in dichloromethane Reflux;
参考文献
Loy, Nicole S. Y.; Singh, Alok; Xu, Xianxiu; Park, Cheol-Min
Angewandte Chemie - International Edition, 2013 , vol. 52, # 8 p. 2212 - 2216
Angew. Chem., vol. 125, # 8 p. 2268 - 2272,5
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere 1.2: 3 h / -78 °C 2.1: manganese(IV) oxide / dichloromethane / |Reflux View Scheme
参考文献
Loy, Nicole S. Y.; Singh, Alok; Xu, Xianxiu; Park, Cheol-Min
Angewandte Chemie - International Edition, 2013 , vol. 52, # 8 p. 2212 - 2216
Angew. Chem., vol. 125, # 8 p. 2268 - 2272,5
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 5 h;
参考文献
Hogenkamp, Derk J.; Johnstone, Timothy B. C.; Huang, Jin-Cheng; Li, Wen-Yen; Tran, Minhtam; Whittemore, Edward R.; Bagnera, Rudy E.; Gee, Kelvin W.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3369 - 3379
