1: phenylmethylphosphonic acid,diethyl ester With 18-crown-6 ether; sodium methylate in N,N-dimethyl-formamide
T=20°C; 0.0833333 h;
2: pyridine-3-aldehyde in N,N-dimethyl-formamide
T=20 - 120°C; Horner-Emmons-Wadsworth reaction; 6 h;
参考文献
Heynekamp, Justin J.; Weber, Waylon M.; Hunsaker, Lucy A.; Gonzales, Amanda M.; Orlando, Robert A.; Deck, Lorraine M.; Vander Jagt, David L.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 7182 - 7189