2,4,6-三甲基苯溴化镁合成路线 （共 186 条）
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With PEPPSITM-IPr; zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran
T=70°C; 2.5 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
反应条件
1: tetrahydrofuran; 1,4-dioxane / 2 h / -30 - 20 °C / |Inert atmosphere
2: tetrahydrofuran / 2.5 h / 70 °C
View Scheme
参考文献
Sun, Chang-Liang; Krause, Helga; Fuerstner, Alois
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 6 p. 1281 - 1291
参考文献
Tsutsui, M.; Levy, M. N.
Zeitschrift fuer Naturforschung, 1966 , vol. 21b, p. 823 - 827
Full Text Show Details
Gmelin Handbook: Cr: Org.Verb., 1.6.2.1.4, page 352 - 355
反应条件
diethyl ether; methyl-chloromethyl ether; magnesium
Reagens 4: CuCl2;
参考文献
Lapkin; Lapkina
Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 108,112,114;engl.Ausg.S.21 119
Zhurnal Obshchei Khimii, 1952 , vol. 22, p. 1602,1607;engl.Ausg.S.22 1643
参考文献
Lapkin; Lapkina
Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 108,112,114;engl.Ausg.S.21 119
Zhurnal Obshchei Khimii, 1952 , vol. 22, p. 1602,1607;engl.Ausg.S.22 1643
参考文献
Carre
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1910 , vol. 151, p. 150
Bulletin de la Societe Chimique de France, 1910 , vol. <4> 7, p. 842
参考文献
Lapkin; Lapkina
Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 108,112,114;engl.Ausg.S.21 119
Zhurnal Obshchei Khimii, 1952 , vol. 22, p. 1602,1607;engl.Ausg.S.22 1643
反应条件
2: glacial acetic acid; HBr / 100 °C
View Scheme
参考文献
Carre
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1910 , vol. 151, p. 150
Bulletin de la Societe Chimique de France, 1910 , vol. <4> 7, p. 842
反应条件
2: alkaline permanganate
View Scheme
参考文献
Carre
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1910 , vol. 151, p. 150
Bulletin de la Societe Chimique de France, 1910 , vol. <4> 7, p. 842
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With zinc(II) chloride−TMEDA; 1-phenyl-1H-pyrazole in tetrahydrofuran
T=0°C; 0.05 h; Schlenk techniqueInert atmosphere;
2: 3-phenoxy-1-propene With iron (III) acetylacetonate; 4,4'-di-tert-butyl-2,2'-dipyridyl in tetrahydrofuran
T=0°C; 16 h; Schlenk techniqueInert atmosphere;
参考文献
Asako, Sobi; Norinder, Jakob; Ilies, Laurean; Yoshikai, Naohiko; Nakamura, Eiichi
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 7 p. 1481 - 1485
