2,4,6-三甲基苯溴化镁合成路线 （共 186 条）
反应条件
PEPPSI™-IPr catalyst in tetrahydrofuran T=20°C; Kumada-Tamao-Corriu reaction; 24 h;
参考文献
Total Synthesis, Ltd.
Patent: US2007/73055 A1, 2007 ;
Location in patent: Page/Page column 13-14; 24 ;
反应条件
in diethyl ether soln. of the Grignard reagent added to a soln. of the complex, refluxed (4 h); filtered, evapn. (vac.), brown-black residue extd. (hexane), concd., filtered, concd., filtered, cooled, crystn.; elem. anal.;
参考文献
Hay-Motherwell, Robyn S.; Wilkinson, Geoffrey; Hussain-Bates, Bilquis; Hursthouse, Michael B.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1992 , # 24 p. 3477 - 3482
参考文献
Bailey; Turek
Journal of the American Oil Chemists' Society, 1956 , vol. 33, p. 317
参考文献
Kohler, Erickson
Journal of the American Chemical Society, 1931 , vol. 53, p. 2301,2307
反应条件
in tetrahydrofuran T=0°C; 0.166667 h;
参考文献
Koo, Ja Seo; Lee, Jae In
Synthetic Communications, 1996 , vol. 26, # 20 p. 3709 - 3713
反应条件
phosphorus trichoride in tetrahydrofuran T=-78°C;
参考文献
Sasaki, Shigeru; Murakami, Fumiki; Yoshifuji, Masaaki
Tetrahedron Letters, 1997 , vol. 38, # 40 p. 7095 - 7098
反应条件
phosphorus trichoride in tetrahydrofuran T=-50°C; further reagent: PBr3; Yield given. Title compound not separated from byproducts;
参考文献
Schmidbaur, Hubert; Schnatterer, Stefan
Chemische Berichte, 1983 , vol. 116, # 5 p. 1947 - 1954
反应条件
1: 80 percent / tetrahydrofuran / 0 - 20 °C 2: 75 percent / triisobutylaluminum / toluene / 24 h / 70 °C View Scheme
参考文献
Busacca, Carl A.; Lorenz, Jon C.; Grinberg, Nelu; Haddad, Nizar; Hrapchak, Matt; Latli, Bachir; Lee, Heewon; Sabila, Paul; Saha, Anjan; Sarvestani, Max; Shen, Sherry; Varsolona, Richard; Wei, Xudong; Senanayake, Chris H.
Organic Letters, 2005 , vol. 7, # 19 p. 4277 - 4280
反应条件
in tetrahydrofuran; diethyl ether
参考文献
Bordwell, Frederick G.; Cheng, Jin-Pei; Bausch, Mark J.
Journal of the American Chemical Society, 1988 , vol. 110, # 9 p. 2867 - 2872
反应条件
lithium aluminium tetrahydride; trichlorosilane in diethyl ether T=-78 - 20°C; 3.17 h; Inert atmosphere;
参考文献
Tran, Ngon T.; Min, Taewoo; Franz, Annaliese K.
Chemistry - A European Journal, 2011 , vol. 17, # 36 p. 9897 - 9900
