顺-均二苯乙烯硼酸频哪酸酯合成路线 (共 6 条)
反应条件
1: 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane With potassium tert-butylate; tris-(o-tolyl)phosphine; copper(l) chloride in tetrahydrofuran 0.166667 h; Inert atmosphere; 2: diphenyl acetylene With methanol in tetrahydrofuran T=20°C; Inert atmosphere; regioselective reaction;
参考文献
Kim, Hye Ryung; Yun, Jaesook
Chemical Communications, 2011 , vol. 47, # 10 p. 2943 - 2945
反应条件
1: 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane With copper(II) hydroxide carbonate; triphenylphosphine in water T=20°C; 0.5 h; Inert atmosphere; 2: PhCH=CHPh T=27°C; 24 h;
参考文献
LEK PHARMACEUTICALS D.D.; STAVBER, Gaj; CASAR, Zdenko
Patent: WO2013/150125 A1, 2013 ;
Location in patent: Page/Page column 31 ;
反应条件
2,6-bis[1-((2,6-diethylphenyl)imino)ethyl]pyridine; ethylmagnesium bromide; iron(II) chloride in tetrahydrofuran; diethyl ether T=20°C; 1 h; Inert atmosphere; stereoselective reaction;
参考文献
Greenhalgh, Mark D.; Thomas, Stephen P.
Chemical Communications, 2013 , vol. 49, # 95 p. 11230 - 11232
反应条件
2Fe(1+)*9CO in toluene T=100°C; 24 h; Inert atmosphere; Overall yield = > 99 percent;
参考文献
Haberberger, Michael; Enthaler, Stephan
Chemistry - An Asian Journal, 2013 , vol. 8, # 1 p. 50 - 54
反应条件
1: diphenyl acetylene; 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane With [Pt(PPh3)4] in 1,4-dioxane T=180°C; 0.5 h; microwave irradiation; 2: iodobenzene With potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=140°C; Suzuki cross-coupling reaction; 0.5 h; microwave irradiation; Further stages.;
参考文献
Prokopcova, Hana; Ramirez, Jesus; Fernandez, Elena; Kappe, C. Oliver
Tetrahedron Letters, 2008 , vol. 49, # 33 p. 4831 - 4835
反应条件
1: diphenyl acetylene; 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane With [Pt(PPh3)4] in 1,4-dioxane T=180°C; 0.5 h; microwave irradiation; 2: bromobenzene With potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=140°C; Suzuki cross-coupling reaction; 0.5 h; microwave irradiation; Further stages.;
参考文献
Prokopcova, Hana; Ramirez, Jesus; Fernandez, Elena; Kappe, C. Oliver
Tetrahedron Letters, 2008 , vol. 49, # 33 p. 4831 - 4835