4-(溴甲基)苯甲酸乙酯合成路线 （共 44 条）
反应条件
diethylzinc; tetrakis(triphenylphosphine) palladium(0) in hexane; N,N-dimethyl-formamide T=25°C; 1 h; Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 58, # 24 p. 6908 - 6910
反应条件
meta-chloroperoxybenzoic acid; tri-n-butyl-tin hydride in benzene T=90°C; 12 h; in the presence of α-bromotoluene (competitor), relative reactivity; Mechanism;
参考文献
Journal of the American Chemical Society, , vol. 102, # 2 p. 692 - 697
反应条件
dibenzyl phosphine oxide; sodium hydride in toluene 3 h; Heating;
参考文献
Phosphorus, Sulfur and Silicon and Related Elements, , vol. 108, # 1-4 p. 169 - 187
反应条件
sodium hydride in toluene 3 h; Heating;
参考文献
Phosphorus, Sulfur and Silicon and Related Elements, , vol. 108, # 1-4 p. 169 - 187
反应条件
sodium hydride in toluene 3 h; Heating;
参考文献
Phosphorus, Sulfur and Silicon and Related Elements, , vol. 108, # 1-4 p. 169 - 187
反应条件
potassium hydroxide in water 0.5 h;
参考文献
Sun, Libo; Xing, Hongzhu; Liang, Zhiqiang; Yu, Jihong; Xu, Ruren
Chemical Communications, 2013 , vol. 49, # 95 p. 11155 - 11157
反应条件
1: 1.) NaOEt / 1.) ethanol, 2.) ethanol, 5 h, reflux 2: 1.) aq. NaOH, 2.) acetic acid, 3.) 12 M aq. HCl 3: 64 percent / Et3N / tetrahydrofuran; H2O / 24 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 23 p. 4660 - 4669
反应条件
1: 1.) 18-crown-6, KOC(CH3)3 / 1.) diethyl ether, 15 min; 2.) diethyl ether, 2 h at 0°C then overnight at room temp. 2: 66 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Silvestri; Pagnozzi; Valoti; Fusi
Farmaco, 1994 , vol. 49, # 10 p. 625 - 632
反应条件
1: 1.) 18-crown-6, KOC(CH3)3 / 1.) THF, 15 min; 2.) THF, 2 h at 0°C then overnight at room temp. 2: 57 percent / 10percent aq. KOH / ethanol / 3 h / Heating View Scheme
参考文献
Silvestri; Pagnozzi; Valoti; Fusi
Farmaco, 1994 , vol. 49, # 10 p. 625 - 632
反应条件
1: 1.) 18-crown-6, KOC(CH3)3 / 1.) diethyl ether, 15 min; 2.) diethyl ether, 2 h at 0°C then overnight at room temp. 2: 86 percent / 10percent aq. KOH / ethanol / 3 h / Heating View Scheme
参考文献
Silvestri; Pagnozzi; Valoti; Fusi
Farmaco, 1994 , vol. 49, # 10 p. 625 - 632
