4-(溴甲基)苯甲酸乙酯合成路线 （共 44 条）
参考文献
METABASIS THERAPEUTICS, INC.; GOMEZ-GALENO, Jorge, E.; HECKER, Scott, J.; DANG, Qun; GROTE, Matthew, P.
Patent: WO2010/19828 A1, 2010 ;
Location in patent: Page/Page column 42 ;
WO 2010/019828 A1
反应条件
in dichloromethane
T=90 - 140°C; 2 h;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/192729 A1, 2004 ;
Location in patent: Page 33-34 ;
参考文献
Allergan, Inc.
Patent: US5399586 A1, 1995 ;
反应条件
sodium hydride in toluene
3 h; Heating;
参考文献
Witt, Dariusz; Rachon, Janusz
Phosphorus, Sulfur and Silicon and Related Elements, 1996 , vol. 108, # 1-4 p. 169 - 187
参考文献
Ding, Derong; Yan, Guang
Chinese Journal of Chemistry, 2012 , vol. 30, # 8 p. 1906 - 1908
反应条件
in ethanol; water
T=20°C; 15 h; Heating / reflux;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/242572 A1, 2004 ;
Location in patent: Page/Page column 34 ;
参考文献
Anand, Ramesh C.; Milhotra, Archana
Chemical Communications, 1999 , # 15 p. 1415 - 1415
反应条件
potassium fluoride; 18-crown-6 ether in acetonitrile
92 h; Heating;
参考文献
Dawson, Marcia I.; Chan, Rebecca; Hobbs, Peter D.; Chao, Wan-ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1282 - 1293
反应条件
1: 70 percent / NaOBu / Ambient temperature
2: NaOH
3: SOCl2 / benzene / Heating
View Scheme
参考文献
Wan, A. S. C.; Ngiam, T. L.; Leung, S. L.; Go, M. L.; Heng, P. W. S.; et al.
Steroids, 1983 , vol. 41, # 3 p. 309 - 320
反应条件
sodium n-butanolate
Ambient temperature;
参考文献
Wan, A. S. C.; Ngiam, T. L.; Leung, S. L.; Go, M. L.; Heng, P. W. S.; et al.
Steroids, 1983 , vol. 41, # 3 p. 309 - 320
