(R)-(-)-2-己醇合成路线 （共 34 条）
反应条件
1: propyl bromide With methylmagnesium bromide; magnesium in tetrahydrofuran T=0°C; 1 h; Inert atmosphere; 2: (R)-(+)-propylene oxide With copper dilithium tetrachloride in tetrahydrofuran T=-78 - 20°C; 1.5 h; Inert atmosphere; 3: With water; ammonium chloride in tetrahydrofuran Inert atmosphereCooling with ice;
参考文献
Taguri, Tomonori; Yamakawa, Rei; Fujii, Toru; Muraki, Yuta; Ando, Tetsu
Tetrahedron Asymmetry, 2012 , vol. 23, # 11-12 p. 852 - 858
反应条件
yeast Enzymatic reaction; Conversion of starting material;
参考文献
Council of Scientific and Industrial Research
Patent: US7056540 B2, 2006 ;
Location in patent: Page/Page column 10 ;
反应条件
copper(l) iodide in tetrahydrofuran T=0°C;
参考文献
Merlo; Gallardo
Synthetic Communications, 1993 , vol. 23, # 15 p. 2159 - 2169
反应条件
methanol; toluene-4-sulfonic acid in dichloromethane 1 h; Ambient temperature;
参考文献
Noe, Christian R.; Knollmueller, M.; Dungler, K.; Miculka, C.; Gaertner, P.
Monatshefte fuer Chemie, 1991 , vol. 122, # 8 p. 705 - 718
反应条件
Leifsonia sp. S749 cells alcohol dehydrogenase; β-NADP+; isopropyl alcohol in phosphate buffer T=25°C; pH=7.0; 24 h;
参考文献
Inoue, Kousuke; Makino, Yoshihide; Itoh, Nobuya
Tetrahedron Asymmetry, 2005 , vol. 16, # 15 p. 2539 - 2549
反应条件
1: With (-)-(S)-[2-(2-methoxynaphthalen-1yl)phenyl]diphenylphosphine; trichlorosilane; bis(η3-allyl-μ-chloropalladium(II)) T=40°C; 24 h; 2: With potassium fluoride; potassium hydrogencarbonate in tetrahydrofuran; methanol T=20°C; 0.333333 h; 3: With dihydrogen peroxide in tetrahydrofuran; methanol T=20°C; 12 h; Title compound not separated from byproducts;
参考文献
Heller, Barbara; Gutnov, Andrey; Fischer, Christine; Drexler, Hans-Joachim; Spannenberg, Anke; Redkin, Dmitry; Sundermann, Corinna; Sundermann, Bernd
Chemistry - A European Journal, 2007 , vol. 13, # 4 p. 1117 - 1128
反应条件
1: With [RuCl2(p-cumene)]2; trifuran-2-yl-phosphane; sodium carbonate in toluene T=50°C; Schlenk techniqueInert atmosphere; 2: With bis(norbornadiene)rhodium(I) tetrafluoroborate; C46H35NO2P2; hydrogen in tetrahydrofuran T=20°C; P=15001.5 Torr; 1 h; Schlenk techniqueInert atmosphereAutoclave; 3: With potassium hydroxide in methanol T=20°C; Schlenk techniqueInert atmosphere; Overall yield = 54 percent; Overall yield = 33.5 mg; enantioselective reaction;
参考文献
Konrad, Tina Maria; Schmitz, Pascal; Leitner, Walter; Francio, Giancarlo
Chemistry - A European Journal, 2013 , vol. 19, # 40 p. 13299 - 13303
反应条件
1: trichlorosilane; [(R)-1,1'-spirobiindane-7,7'-dioxy][((R)-PhMeCH)2N]phosphane / [Pd(η3-allyl)Cl]2 / benzene / 72 h / 40 °C 2: H2O2; KF; KHCO3 / methanol; tetrahydrofuran View Scheme
参考文献
Guo, Xun-Xiang; Xie, Jian-Hua; Hou, Guo-Hua; Shi, Wen-Jian; Wang, Li-Xin; Zhou, Qi-Lin
Tetrahedron Asymmetry, 2004 , vol. 15, # 14 p. 2231 - 2234
反应条件
1: 1-methyl-1-pentanol With Candida antarctica lipase B in isopropyl alcohol T=30°C; 0.5 h; Enzymatic reaction; 2: vinyl acetate in isopropyl alcohol T=30°C; 0.1 h; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Ema, Tadashi; Ura, Norichika; Yoshii, Masataka; Korenaga, Toshinobu; Sakai, Takashi
Tetrahedron, 2009 , vol. 65, # 46 p. 9583 - 9591
反应条件
(1R,2R)-(+)-1,2-diphenylethylenediamine in ethanol Title compound not separated from byproducts;
参考文献
Imai, Yoshitane; Sato, Tomohiro; Kuroda, Reiko
Chemical Communications, 2005 , # 26 p. 3289 - 3291
