3-硝基-4-哌啶-1-苯甲酸合成路线 （共 10 条）
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 5 h; 2: With acetic acid in water pH=5;
参考文献
MERCK SERONO S.A.
Patent: WO2009/43889 A2, 2009 ;
Location in patent: Page/Page column 117-118 ;
WO 2009/043889 A2
反应条件
in tetrahydrofuran T=20°C; 24 h;
参考文献
Correa, N. Mariano; Durantini, Edgardo N.; Silber, Juana J.
Journal of Physical Organic Chemistry, 2005 , vol. 18, # 2 p. 121 - 127
反应条件
1: sulfuric acid; chromic acid / 30 - 50 °C 2: water View Scheme
参考文献
Goldstein; Voegeli
Helvetica Chimica Acta, 1943 , vol. 26, p. 475,480
参考文献
Goldstein; Voegeli
Helvetica Chimica Acta, 1943 , vol. 26, p. 475,480
反应条件
sulfuric acid; acetic acid
参考文献
Borsche; Stackmann; Makaroff-Semljanski
Chemische Berichte, 1916 , vol. 49, p. 2230
反应条件
1: sodium acetate; alcohol 2: sulfuric acid; acetic acid View Scheme
参考文献
Borsche; Stackmann; Makaroff-Semljanski
Chemische Berichte, 1916 , vol. 49, p. 2230
反应条件
1: sodium acetate; alcohol 2: sulfuric acid; acetic acid View Scheme
参考文献
Borsche; Stackmann; Makaroff-Semljanski
Chemische Berichte, 1916 , vol. 49, p. 2230
参考文献
Le Fevre; Turner
Journal of the Chemical Society, 1927 , p. 1117
反应条件
hydrogen; acetic acid; palladium on activated charcoal in methanol; ethyl acetate P=760.051 Torr;
参考文献
Patch, Raymond J.; Brandt, Benjamin M.; Asgari, Davoud; Baindur, Nand; Chadha, Naresh K.; Georgiadis, Taxiarchis; Cheung, Wing S.; Petrounia, Ioanna P.; Donatelli, Robert R.; Chaikin, Margery A.; Player, Mark R.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 22 p. 6070 - 6074
反应条件
1: Cl(CO)2Cl, DMF / CH2Cl2 / Ambient temperature
2: AlCl3 / Ambient temperature
View Scheme
参考文献
Parlow, John J.; Mischke, Deborah A.; Woodard, Scott S.
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 5908 - 5919
