2-吗啉基-5-硝基吡啶合成路线 （共 15 条）
反应条件
triethylamine in dichloromethane T=20°C; 3 h;
参考文献
Bolin, David Robert; Cheung, Adrian Wai-Hing; Firooznia, Fariborz; Hamilton, Matthew Michael; Li, Shiming; McDermott, Lee Apostle; Qian, Yimin; Yun, Weiya
Patent: US2007/123504 A1, 2007 ;
Location in patent: Page/Page column 12 ;
US 20070123504 A1
反应条件
in dichloromethane 4 h; Reflux;
参考文献
RIGEL PHARMACEUTICALS, INC.
Patent: US2010/190770 A1, 2010 ;
Location in patent: Page/Page column 85 ;
反应条件
AgPy2MNo4 T=8 - 10°C; 0.5 h;
参考文献
Gulevskaya, Anna V.; Maes, Bert U. W.; Meyers, Caroline; Herrebout, Wouter A.; Van Der Veken, Benjamin J.
European Journal of Organic Chemistry, 2006 , # 23 p. 5305 - 5314
反应条件
triethylamine in dichloromethane T=23°C; 3 h;
参考文献
Yun, Weiya; Ahmad, Mushtaq; Chen, Yingsi; Gillespie, Paul; Conde-Knape, Karin; Kazmer, Sonja; Li, Shiming; Qian, Yimin; Taub, Rebecca; Wertheimer, Stanley J.; Whittard, Toni; Bolin, David
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 23 p. 7205 - 7209
反应条件
1.1: sodium hydroxide / acetonitrile / Heating 1.2: 20 °C 2.1: acetonitrile / 45 °C View Scheme
参考文献
Khattab, Sherine N.; Hamed, Ezzat Awad; Albericio, Fernando; El-Faham, Ayman
Bulletin of the Chemical Society of Japan, 2011 , vol. 84, # 6 p. 633 - 639
反应条件
in ethanol T=20°C; 2 h;
参考文献
Charushin, Valery N.; Plas, Henk C. van der
Journal of Organic Chemistry, 1983 , vol. 48, # 16 p. 2667 - 2671
Title/Abstract Full Text View citing articles Show Details
Marcelis, Antonius T. M.; Plas, Henk C. van der
Tetrahedron, 1989 , vol. 45, # 9 p. 2693 - 2702
反应条件
1: With KHF2 in methanol; water T=0 - 20°C; 0.0333333 h; Inert atmosphere; 2: With NOBF4 in acetonitrile T=20°C; 0.00833333 h;
参考文献
Molander, Gary A.; Cavalcanti, Livia N.
Journal of Organic Chemistry, 2012 , vol. 77, # 9 p. 4402 - 4413
反应条件
in methanol T=25°C; 0.5 h; various solvents; Rate constantKineticsMechanism;
参考文献
Hamed, Ezzat A.
International Journal of Chemical Kinetics, 1997 , vol. 29, # 8 p. 599 - 605
反应条件
in acetonitrile T=45°C; Kinetics; Temperature;
参考文献
Khattab, Sherine N.; Hamed, Ezzat Awad; Albericio, Fernando; El-Faham, Ayman
Bulletin of the Chemical Society of Japan, 2011 , vol. 84, # 6 p. 633 - 639
反应条件
in acetonitrile T=45°C; Kinetics; Temperature;
参考文献
Khattab, Sherine N.; Hamed, Ezzat Awad; Albericio, Fernando; El-Faham, Ayman
Bulletin of the Chemical Society of Japan, 2011 , vol. 84, # 6 p. 633 - 639
