1-氧代-2,8-二氮杂螺[4.5]癸烷-8-羧酸叔丁酯合成路线 （共 9 条）
反应条件
potassium carbonate in tetrahydrofuran; water pH=~ 10;
参考文献
WO2005/84667 A1, ;
Page/Page column 78 ;
WO 2005/084667 A1
反应条件
1.1: triethylamine / tetrahydrofuran; water 2.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C 2.2: 20 °C 3.1: sodium azide / N,N-dimethyl-formamide / 90 °C 4.1: 10 Pd/C; hydrogen / ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 22 p. 6876 - 6881,6
反应条件
1: sodium azide / N,N-dimethyl-formamide / 90 °C 2: 10 Pd/C; hydrogen / ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 22 p. 6876 - 6881,6
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C 1.2: 20 °C 2.1: sodium azide / N,N-dimethyl-formamide / 90 °C 3.1: 10 Pd/C; hydrogen / ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 22 p. 6876 - 6881,6
反应条件
10 Pd/C; hydrogen in ethanol
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 22 p. 6876 - 6881,6
反应条件
1.1: triethylamine / tetrahydrofuran; water 2.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C 2.2: 20 °C 3.1: sodium azide / N,N-dimethyl-formamide / 90 °C 4.1: 10 Pd/C; hydrogen / ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 22 p. 6876 - 6881,6
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -65 °C / |Inert atmosphere 1.2: -65 - 20 °C / |Inert atmosphere 2.1: ammonium hydroxide; hydrogen / methanol / 18 h / 50 °C / 15001.5 Torr View Scheme
参考文献
WO2014/15495 A1, ;
WO2014/18764 A1, ;
反应条件
trifluoroacetic acid in dichloromethane
参考文献
MERCK SHARP and DOHME CORP.; DING, Fa-Xiang; DONG, Shuzhi; FRIE, Jessica; GU, Xin; JIANG, Jinlong; PASTERNAK, Alexander; TANG, Haifeng; WU, Zhicai; YU, Yang; SUZUKI, Takao
Patent: WO2014/18764 A1, 2014 ;
Location in patent: Page/Page column 113 ;
反应条件
1: tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate With sodium hydride in DMF (N,N-dimethyl-formamide)
T=20°C; 1 h;
2: 4-bromo-benzyl bromide in DMF (N,N-dimethyl-formamide)
T=20°C; 1 h;
参考文献
VIROCHEM PHARMA INC.
Patent: WO2005/23809 A1, 2005 ;
Location in patent: Page/Page column 70-71 ;
WO 2005/023809 A1
