4-甲基-3-氧代四氢噻吩-2-甲酸甲酯合成路线 （共 5 条）
反应条件
titanium tetrachloride; triethylamine 1) CH2Cl2, -10 deg C, 0.5 h; 2) CH2Cl2, -10 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Sharps Associates
Patent: US3946111 A1, 1976 ;
反应条件
hydroxylamine hydrochloride; barium carbonate in diethyl ether; water; isopropyl alcohol
参考文献
Bayer Aktiengesellschaft
Patent: US6180567 B2, 2001 ;
反应条件
sodium methylate in methanol
参考文献
Byk Gulden Lomberg Chemische Fabrik GmbH
Patent: US4272507 A1, 1981 ;
反应条件
sodium hydride T=0°C; 8.5 h;
参考文献
Liu, Hsing-Jang; Ngooi, Teng Ko
Canadian Journal of Chemistry, 1982 , vol. 60, p. 437 - 439
反应条件
MH2OH*HCl in acetonitrile 5 h; Heating;
参考文献
Barker, John M.; Huddleston, Patrick R.; Wood, Michael L.
Synthetic Communications, 2002 , vol. 32, # 16 p. 2565 - 2568
