1,2,3,4,5,6,7,8-八氢苯并[4,5]噻吩并[2,3-d]嘧啶-2,4-二酮合成路线

27285-09-21,2,3,4,5,6,7,8-八氢苯并[4,5]噻吩并[2,3-d]嘧啶-2,4-二酮

参考文献

Venskutonyte, Raminta; Butini, Stefania; Sanna Coccone, Salvatore; Gemma, Sandra; Brindisi, Margherita; Kumar, Vinod; Guarino, Egeria; Maramai, Samuele; Valenti, Salvatore; Amir, Ahmad; Valades, Elena Anton; Frydenvang, Karla; Kastrup, Jette S.; Novellino, Ettore; Campiani, Giuseppe; Pickering, Darryl S.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4793 - 4805

4506-71-22-氨基-4,5,6,7-四氢苯并噻酚-3-羧酸乙酯+

57-13-6尿素

27285-09-21,2,3,4,5,6,7,8-八氢苯并[4,5]噻吩并[2,3-d]嘧啶-2,4-二酮

参考文献

NIMBUS IRIS, INC.; ROMERO, Donna L.; ROBINSON, Shaughnessy; WESSEL, Matthew David; GREENWOOD, Jeremy Robert
Patent: WO2014/11902 A1, 2014 ;
Location in patent: Paragraph 00363 ;

4506-71-22-氨基-4,5,6,7-四氢苯并噻酚-3-羧酸乙酯

27285-09-21,2,3,4,5,6,7,8-八氢苯并[4,5]噻吩并[2,3-d]嘧啶-2,4-二酮

参考文献

Wamhoff, Heinrich; Ertas, Muemtaz
Synthesis, 1985 , # 2 p. 190 - 194

108354-78-52-氨基-4,5,6,7-四氢苯并噻酚-3-羧酸乙酯

27285-09-21,2,3,4,5,6,7,8-八氢苯并[4,5]噻吩并[2,3-d]嘧啶-2,4-二酮

参考文献

Venskutonyte, Raminta; Butini, Stefania; Sanna Coccone, Salvatore; Gemma, Sandra; Brindisi, Margherita; Kumar, Vinod; Guarino, Egeria; Maramai, Samuele; Valenti, Salvatore; Amir, Ahmad; Valades, Elena Anton; Frydenvang, Karla; Kastrup, Jette S.; Novellino, Ettore; Campiani, Giuseppe; Pickering, Darryl S.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4793 - 4805

108-94-1环己酮

27285-09-21,2,3,4,5,6,7,8-八氢苯并[4,5]噻吩并[2,3-d]嘧啶-2,4-二酮

参考文献

NIMBUS IRIS, INC.; ROMERO, Donna L.; ROBINSON, Shaughnessy; WESSEL, Matthew David; GREENWOOD, Jeremy Robert
Patent: WO2014/11902 A1, 2014 ;

27285-13-8

27285-09-21,2,3,4,5,6,7,8-八氢苯并[4,5]噻吩并[2,3-d]嘧啶-2,4-二酮

参考文献

Sauter,F.
Monatshefte fuer Chemie, 1970 , vol. 101, p. 535 - 543

75-44-5光气+

4815-28-52-氨基-4,5,6,7-四氢苯并[b]噻吩-3-甲酰胺

27285-09-21,2,3,4,5,6,7,8-八氢苯并[4,5]噻吩并[2,3-d]嘧啶-2,4-二酮

参考文献

Sauter,F.
Monatshefte fuer Chemie, 1970 , vol. 101, p. 535 - 543

40277-35-8

27285-09-21,2,3,4,5,6,7,8-八氢苯并[4,5]噻吩并[2,3-d]嘧啶-2,4-二酮

参考文献

Boehm, R.; Pech, R.; Haubold, Gudrun; Hannig, E.
Pharmazie, 1986 , vol. 41, # 1 p. 23 - 25

57-13-6尿素+

4815-28-52-氨基-4,5,6,7-四氢苯并[b]噻吩-3-甲酰胺

27285-09-21,2,3,4,5,6,7,8-八氢苯并[4,5]噻吩并[2,3-d]嘧啶-2,4-二酮

参考文献

Gakhar,H.K. et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1978 , vol. 16B, p. 940 - 942

27285-09-21,2,3,4,5,6,7,8-八氢苯并[4,5]噻吩并[2,3-d]嘧啶-2,4-二酮

40277-35-8

参考文献

Ishikawa, Fumiyoshi; Kosasayama, Akira; Yamaguchi, Hitoshi; Watanabe, Yoshifumi; Saegusa, Junji; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 4 p. 376 - 382