1,2,3-噻唑(1,5-a)吡啶合成路线 （共 26 条）
反应条件
n-butyllithium; bromine; diisopropylamine
1.) hexane, -40 deg C, 6 h, 2.) - 40 deg C; Yield given. Multistep reaction;
参考文献
Jones, Gurnos; Sliskovic, D. Robert
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 967 - 972
反应条件
chlorine; calcium carbonate in tetrachloromethane
T=5°C; other electrophiles; MechanismProduct distribution;
参考文献
Jones, Gurnos; Sliskovic, D. Robert; Foster, Beverley; Rogers, John; Smith, Anthony K.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 78 - 81
反应条件
5 Pd(OH)2/C; zinc in water
T=150°C; 24 h; Autoclave;
参考文献
Abarca, Belen; Adam, Rosa; Alom, Shamim; Ballesteros, Rafael; Lopez-Molina, Sonia
Arkivoc, 2014 , vol. 2014, # 2 p. 175 - 186
反应条件
palladium 10 on activated carbon; zinc in ethanol; water
T=150°C; 24 h; Autoclave;
参考文献
Abarca, Belen; Adam, Rosa; Alom, Shamim; Ballesteros, Rafael; Lopez-Molina, Sonia
Arkivoc, 2014 , vol. 2014, # 2 p. 175 - 186
反应条件
palladium diacetate; caesium carbonate; triphenylphosphine
T=140°C; Inert atmosphere;
参考文献
Abarca, Belen; Adam, Rosa; Ballesteros, Rafael; Chiassai, Leonardo; Gamon, Cristina
Arkivoc, 2012 , vol. 2012, # 9 p. 229 - 241
反应条件
1: iodine; potassium hydroxide / dimethylformamide
2: aq. sodium carbonate; Pd(PPh3)4 / dioxane / 24 h / 85 °C
View Scheme
参考文献
Abarca, Belen; Aucejo, Ricardo; Ballesteros, Rafael; Blanco, Fernando; Garcia-Espana, Enrique
Tetrahedron Letters, 2006 , vol. 47, # 46 p. 8101 - 8103
