1-溴-2-(溴甲基)-4-甲基苯合成路线 （共 8 条）
反应条件
phosphorus tribromide in diethyl ether T=0°C; 3 h; Inert atmosphere;
参考文献
ALMIRALL, S.A.; VIDAL JUAN, Bernat; ALONSO DIEZ, Juan Antonio; BUIL ALBERO, Maria Antonia; EASTWOOD, Paul Robert; ESTEVE TRIAS, Cristina; LOZOYA TORIBIO, Maria Estrella; ROBERTS, Richard Spurring; VIDAL GISPERT, Laura; GONZALEZ RODRIGUEZ, Jacob; MIR CEPEDA, Marta
Patent: WO2013/10880 A1, 2013 ;
Location in patent: Page/Page column 151-152 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
参考文献
Pine,S.H. et al.
Journal of Organic Chemistry, 1971 , vol. 36, p. 984 - 991
反应条件
bromine in tetrachloromethane T=-10°C; 0.5 h; reaction regioselectivity; a series of reagents; Product distributionMechanism;
参考文献
Bee, Lim Keow; Garratt, Peter J.; Mansuri, Muzamil M.
Journal of the American Chemical Society, 1980 , vol. 102, # 23 p. 7076 - 7079
反应条件
in chloroform a solution of two equivalents of halogen added dropwise to a solution of organocobaloxime at room temperature under nitrogen in the dark; NMR, UV;
参考文献
Gupta, B. D.; Kumar, Manoj; Roy, Sujit
Inorganic Chemistry, 1989 , vol. 28, p. 11 - 18
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / |Inert atmosphere; |Reflux 2: phosphorus tribromide / diethyl ether / 3 h / 0 °C / |Inert atmosphere View Scheme
参考文献
ALMIRALL, S.A.; VIDAL JUAN, Bernat; ALONSO DIEZ, Juan Antonio; BUIL ALBERO, Maria Antonia; EASTWOOD, Paul Robert; ESTEVE TRIAS, Cristina; LOZOYA TORIBIO, Maria Estrella; ROBERTS, Richard Spurring; VIDAL GISPERT, Laura; GONZALEZ RODRIGUEZ, Jacob; MIR CEPEDA, Marta
Patent: WO2013/10880 A1, 2013 ;
反应条件
in chloroform reaction of solution of Co-compound in dry chloroform with chloroformic soln. of Br2 (2 moles) under N2 at room temp.;
参考文献
Gupta, B. D.; Kumar, Manoj
Chemistry Letters, 1987 , p. 701 - 704
反应条件
(i) Co(dmgH)2py, (ii) Br2; Multistep reaction;
参考文献
Anderson,S.N. et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1972 , p. 311 - 318
参考文献
Bachmann et al.
Journal of the Chemical Society, 1936 , p. 54,60
