1-溴-4-(溴甲基)-2-甲苯合成路线 （共 5 条）
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=20°C; 22 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2011/82165 A1, 2011 ;
Location in patent: Page/Page column 53 ;
参考文献
Hanessian, Stephen; Papeo, Gianluca; Angiolini, Mauro; Fettis, Kamal; Beretta, Marco; Munro, Alexander
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7204 - 7218
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
参考文献
Pine,S.H. et al.
Journal of Organic Chemistry, 1971 , vol. 36, p. 984 - 991
反应条件
1.1: lithium borohydride / tetrahydrofuran / 40.25 h / 0 - 20 °C 1.2: 0 °C 2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 22 h / 20 °C View Scheme
参考文献
GLAXO GROUP LIMITED; JOHNS, Brian Alvin; SHOTWELL, John Brad
Patent: WO2012/67664 A1, 2012 ;
反应条件
tetrabutylammomium bromide in dichloromethane; water 6 h;
参考文献
ASTRAZENECA AB
Patent: WO2008/18827 A1, 2008 ;
Location in patent: Page/Page column 57; 58-59 ;
WO 2008/018827 A1
