1,2-二氨基-4,5-二甲氧基苯合成路线 (共 25 条)
参考文献
Journal of the Chemical Society, , p. 2822,2827
反应条件
1: 1 - 2 h; Heating / reflux; 2: With sodium hydroxide in water pH=8;
参考文献
Boylan, John Frederick; Cai, Jianping; Fotouhi, Nader; Gillespie, Paul; Goodnow, Robert Alan; Le, Kang; Michoud, Christophe
Patent: US2007/203210 A1, 2007 ;
Location in patent: Page/Page column 41 ;
反应条件
in benzene 1 h; Heating;
参考文献
Baudy, Reinhardt B.; Greenblatt, Lynne P.; Jirkovsky, Ivo L.; Conklin, Mary; Russo, Ralph J.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 331 - 342
反应条件
2: diphenylphosphoryl azide (DPPA), Et3N / dimethylformamide 3: benzene / 1 h / Heating 4: benzene / 0.5 h / Heating 5: 81 percent / K2CO3 / ethanol / 6 h / Heating 6: 100 percent / PhI(OAc)2 / CH2Cl2 / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 20 p. 1416 - 1417
反应条件
water in ethanol; acetic acid 2 h; Heating; Yield given;
参考文献
Gazit, Aviv; App, Harald; McMahon, Gerald; Chen, Jefferey; Levitzki, Alexander; Bohmer, Frank D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 11 p. 2170 - 2177
反应条件
Yield given. Multistep reaction;
参考文献
Shimizu, Masato; Takahashi, Tomohiko; Uratsuka, Satoru; Yamada, Sachiko
Journal of the Chemical Society, Chemical Communications, 1990 , # 20 p. 1416 - 1417
反应条件
hydrogen; palladium on activated charcoal
参考文献
Baudy, Reinhardt B.; Greenblatt, Lynne P.; Jirkovsky, Ivo L.; Conklin, Mary; Russo, Ralph J.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 331 - 342
反应条件
1: fuming nitric acid / 2 h
2: H2, conc. HCl / 10percent Pd/C / methanol / 2585.7 Torr
View Scheme
参考文献
Collins, Terrence J.; Powell, Richard D.; Slebodnick, Carla; Uffelman, Erich S.
Journal of the American Chemical Society, 1991 , vol. 113, # 22 p. 8419 - 8425
反应条件
hydrogenchloride; tin(ll) chloride
参考文献
Frisch; Silverman; Bogert
Journal of the American Chemical Society, 1943 , vol. 65, p. 2432
反应条件
palladium monocarbide in methanol
参考文献
Hoechst Aktiengesellschaft; Genetech, Inc.
Patent: US6218415 B1, 2001 ;