5-碘-2-甲氧基苯甲酸合成路线 （共 10 条）
反应条件
sodium hydroxide in methanol; water T=20 - 60°C; 4.25 h;
参考文献
AMGEN INC.
Patent: WO2007/5668 A2, 2007 ;
Location in patent: Page/Page column 44 ;
WO 2007/005668 A2
反应条件
1: With sodium hydride in N,N-dimethyl-formamide T=70°C; 48 h; 2: With lithium hydroxide in water T=70 - 80°C; 2 h; Further stages.;
参考文献
Stark, Daniela; Piel, Markus; Huebner, Harald; Gmeiner, Peter; Gruender, Gerhard; Roesch, Frank
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 21 p. 6819 - 6829
反应条件
iodine; silver nitrate; acetic acid T=20°C;
参考文献
Yusubov, Mekhman S.; Tveryakova, Elena N.; Krasnokutskaya, Elena A.; Perederyna, Irina A.; Zhdankin, Viktor V.
Synthetic Communications, 2007 , vol. 37, # 8 p. 1259 - 1265
反应条件
n-butyllithium; diethyl ether anschliessendes Behandeln mit festem Kohlendioxid;
参考文献
Gilman; Langham; Willis
Journal of the American Chemical Society, 1940 , vol. 62, p. 346
参考文献
Piel, M.; Stark, D.; Rao, M. L.; Frahnert, C.; Schirrmacher, R.; Roesch, F.
Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, p. S161 - S161
反应条件
(i) poly-4-lithium-styrene, Et2O, (ii) /BRN= 1900390/; Multistep reaction;
参考文献
Braun,D.; Seelig,E.
Chemische Berichte, 1964 , vol. 97, p. 3098 - 3105
反应条件
anschliessendes Behandeln mit CO2;
参考文献
Gilman; Langham; Willis
Journal of the American Chemical Society, 1940 , vol. 62, p. 346
反应条件
in diethyl ether; ethanol
参考文献
Syntex (U.S.A.) Inc.
Patent: US5739336 A1, 1998 ;
US 5739336 A
参考文献
De Paulis; Hewlett; Schmidt; Mason; Trivedi; Ebert
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 5 p. 385 - 396
反应条件
hydrogenchloride in sodium hydroxide; dichloromethane; water; acetone
参考文献
THE VANDERBILT UNIVERSITY
Patent: EP320630 A1, 1989 ;
EP 0320630 A1
