(S)-(-)-乳酸甲酯合成路线 （共 55 条）
反应条件
thionyl chloride T=100°C;
参考文献
Dube, Daniel; Brideau, Christine; Deschenes, Denis; Fortin, Rejean; Friesen, Richard W.; Gordon, Robert; Girard, Yves; Riendeau, Denis; Savoie, Chantal; Chan, Chi-Chung
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 12 p. 1715 - 1720
反应条件
1: With di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=-10 - 20°C; 18 h; 2: With hydrogenchloride in ethanol; water
参考文献
Solvay Pharmaceuticals B.V.
Patent: EP1212320 B1, 2005 ;
Location in patent: Page/Page column 6; 8-9 ;
EP 1212320 B1
反应条件
1: (S)-(+)-lactic acid methyl ester With sodium hydride in diethyl ether; ethanol T=-38 - 0°C; 0.333333 h; 2: acrylic acid methyl ester in dimethyl sulfoxide T=20°C; 20 h;
参考文献
Winkler, Christoph K.; Clay, Dorina; Entner, Marcello; Plank, Markus; Faber, Kurt
Chemistry - A European Journal, 2014 , vol. 20, # 5 p. 1403 - 1409
反应条件
N-(chloromethylene)-N-methylmethanaminium chloride 1.) MeCN, 2.) 65 deg C, 16 h; Yield given. Multistep reaction;
参考文献
Barrett, Anthony G. M.; Braddock, D. Christopher; James, Rachel A.; Koike, Nobuyuki; Procopiou, Panayiotis A.
Journal of Organic Chemistry, 1998 , vol. 63, # 18 p. 6273 - 6280
反应条件
(Ru2(η5-C5Ph4O)2(H)2(CO)4); Novozym 435 in toluene T=80°C; 82 h; Schlenk techniqueEnzymatic reaction; stereoselective reaction;
参考文献
Shuklov, Ivan A.; Dubrovina, Natalia V.; Schulze, Joachim; Tietz, Wolfgang; Kuehlein, Klaus; Boerner, Armin
Tetrahedron Letters, 2012 , vol. 53, # 47 p. 6326 - 6328
参考文献
Suganuma, Koto; Horiuchi, Ken; Matsuda, Hironori; Cheng; Aoki, Akihiro; Asakura, Tetsuo
Macromolecules, 2011 , vol. 44, # 23 p. 9247 - 9253
反应条件
Novozym 435; (η5-C5Ph5)Ru(CO)2Cl; potassium tert-butylate T=80°C; Schlenk techniqueEnzymatic reaction;
参考文献
Shuklov, Ivan A.; Dubrovina, Natalia V.; Schulze, Joachim; Tietz, Wolfgang; Kuehlein, Klaus; Boerner, Armin
Tetrahedron Letters, 2012 , vol. 53, # 47 p. 6326 - 6328
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 1 p. 186 - 190
反应条件
72 h; Ambient temperature;
参考文献
Martin, Ricardo; Pascual, Oscar; Romea, Pedro; Rovira, Roser; Urpi, Felix; Vilarrasa, Jaume
Tetrahedron Letters, 1997 , vol. 38, # 9 p. 1633 - 1636
参考文献
BAYER CROPSCIENCE AG
Patent: WO2008/49531 A1, 2008 ;
Location in patent: Page/Page column 6 ;
