1-环状己烯三氟甲烷磺酸合成路线 （共 56 条）
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran
参考文献
Tessier, Pierre E.; Nguyen, Natalie; Clay, Matthew D.; Fallis, Alex G.
Organic Letters, 2005 , vol. 7, # 5 p. 767 - 770
反应条件
sodium carbonate in dichloromethane 24 h; Ambient temperature;
参考文献
Martinez, A. Garcia; Herrera, A.; Martinez, R.; Teso, E.; Garcia, A.; et al.
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1237 - 1241
反应条件
1: cyclohexanone With lithium diisopropyl amide in tetrahydrofuran; ethylene glycol dimethyl ether T=-78°C; Metallation; 2 h; 2: (CF3SO2)2NC6H4-O-(PEG-3400)-OC6H4N(SO2CF3)2 in tetrahydrofuran; ethylene glycol dimethyl ether T=0°C; Acylation; 8 h; Further stages.;
参考文献
Wentworth; Wentworth Jr.; Mansoor; Janda
Organic letters, 2000 , vol. 2, # 4 p. 477 - 480
反应条件
1: cyclohexanone With N,N'-dimethyl-N,N'-propyleneurea; lithium diisopropyl amide in tetrahydrofuran T=-78°C; 2 h; 2: N-phenyl-1,1,1-trifluoromethanesulfonamide in tetrahydrofuran T=0°C; 9 h;
参考文献
Scheiper, Bodo; Bonnekessel, Melanie; Krause, Helga; Fuerstner, Alois
Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3943 - 3949
反应条件
diisopropylamine in tetrahydrofuran; cyclohexanone
参考文献
Abbott Laboratories
Patent: US6307047 B1, 2001 ;
反应条件
Bromoeosine; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=20°C; Flow reactor;
参考文献
Cantillo, David; De Frutos, Oscar; Rincon, Juan A; Mateos, Carlos; Kappe, C. Oliver
Organic Letters, 2014 , vol. 16, # 3 p. 896 - 899
反应条件
polymer-bound 2,6-di-tert-butylpyridine in dichloromethane T=25°C; 24 h; other ketones and aldehydes; var solvents and reaction conditions; Product distribution;
参考文献
Wright, Michael E.; Pulley, Shon R.
Journal of Organic Chemistry, 1987 , vol. 52, # 22 p. 5036 - 5037
反应条件
in neat (no solvent) equiv. amts. of educts, at -15 - 0°C, 6 days;
参考文献
Dueber, T. E.; Stang, P. J.; Pfeifer, W. D.; et al.
Angewandte Chemie, 1970 , vol. 9, p. 521 - 522
Angewandte Chemie, 1970 , vol. 82, p. 517 - 518
反应条件
in dichloromethane T=20°C;
参考文献
Rudler, Henri; Parlier, Andree; Denneval, Charline; Herson, Patrick
Journal of Fluorine Chemistry, 2010 , vol. 131, # 6 p. 738 - 741
反应条件
1.1: Co(acetylacetonate)3 / tetrahydrofuran / 12 h / 20 °C / |Inert atmosphere 2.1: copper(I) thiophene-2-carboxylate / 1,2-dichloro-ethane / 20 °C / |Inert atmosphere; |Sealed tube 2.2: 60 °C / |Inert atmosphere; |Sealed tube 2.3: 60 °C / |Inert atmosphere; |Sealed tube View Scheme
参考文献
Alford, Joshua S.; Spangler, Jillian E.; Davies, Huw M.L.
Journal of the American Chemical Society, 2013 , vol. 135, # 32 p. 11712 - 11715
