反式-2,5-二甲基哌嗪合成路线 （共 29 条）
反应条件
T=220°C; P=62518.2 Torr;
参考文献
Langdon; Levis; Jackson
Ind.eng.Chem.Process Design Devel., 1962 , vol. 1, p. 153
反应条件
T=180 - 225°C; Equilibrium constant;
参考文献
Wyandotte Chem.Corp.
Patent: US3067201 , 1955 ;
反应条件
dextrorotatory cis-form;
参考文献
Hoyer
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1901 , vol. 34, p. 350
参考文献
Stoehr
Journal fuer Praktische Chemie (Leipzig), 1893 , vol. <2> 47, p. 494,506, 508
Journal fuer Praktische Chemie (Leipzig), 1897 , vol. 55, p. 51
参考文献
Godchot; Mousseron
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1930 , vol. 190, p. 800
Bulletin de la Societe Chimique de France, 1932 , vol. <4>51, p. 355
参考文献
PFIZER INC.
Patent: WO2008/96260 A1, 2008 ;
Location in patent: Page/Page column 41 ;
WO 2008/096260 A1
反应条件
T=180 - 225°C; Equilibrium constant;
参考文献
Wyandotte Chem.Corp.
Patent: US3067201 , 1955 ;
反应条件
1: 34.7 percent / acetone / 0.5 h / Heating 2: 33 percent / (+)-camphoric acid / acetone / resolution 3: 98 percent / aqueous NaHCO3 / CHCl3 / 4 h / 20 °C 4: 100 percent / hydrogen; glacial acetic acid / Pd/C / H2O / 3 h / Heating 5: 98 percent / CH2Cl2 / 0 - 20 °C 6: 97 percent / ammonium formate / Pd/C / methanol; H2O / 3 h / Heating View Scheme
参考文献
Janetka, James W.; Furness, M. Scott; Zhang, Xiaoyan; Coop, Andrew; Folk, John E.; Mattson, Mariena V.; Jacobson, Arthur E.; Rice, Kenner C.
Journal of Organic Chemistry, 2003 , vol. 68, # 10 p. 3976 - 3980
参考文献
Oelschlaeger
Arzneimittel Forschung, 1959 , vol. 9, p. 313
Chem.Abstr., 1959 , # 18044
反应条件
1: 34.7 percent / acetone / 0.5 h / Heating 2: 33 percent / (+)-camphoric acid / acetone / resolution View Scheme
参考文献
Calderon, Silvia N.; Rice, Kenner C.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; Kayakiri, Hiroshi; Xu, Heng; Becketts, Karen; Smith, Larren E.; Bilsky, Edward J.; Davis, Peg; Horvath, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 695 - 704
