1-甲基-4-苯基-1,2,3,6-四氢吡啶合成路线 （共 27 条）
反应条件
lithium aluminium tetrahydride; methanol-d1 1.) THF, 0 deg C, 2 h, 2.) -78 deg C; Multistep reaction;
参考文献
Mabic; Castagnoli Jr.
Journal of Organic Chemistry, 1996 , vol. 61, # 1 p. 309 - 313
反应条件
in methanol to a soln. of pyridinium iodide in methanol cooling in an ice bath NaBH4 was added with stirring, mixt. stirred for 15 min at 0°C and 30min at room temp.;
参考文献
Gessner, Wieslaw; Brossi, Arnold
Synthetic Communications, 1985 , vol. 15, # 10 p. 911 - 916
反应条件
in water to a soln. of pyridinium iodide in water (cooled in an ice bath) NaBH4 was added with stirring, mixt. stirred for 15 min at 0°C and 30 min at room temp.; extd. with ether, extract dried over Na2SO4 and evapd. to dryness; chromy. on silica gel column with CH2Cl2; elem. anal.;
参考文献
Gessner, Wieslaw; Brossi, Arnold
Synthetic Communications, 1985 , vol. 15, # 10 p. 911 - 916
反应条件
potassium hydroxide; sodium cyanide 1.) acetic acid / H2SO4; 2.) ethanol, reflux, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Valenta, Vladimir; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 8 p. 2095 - 2106
参考文献
Lyle; Lyle
Journal of Organic Chemistry, vol. 18, p. 1063
参考文献
Buechi et al.
Helvetica Chimica Acta, 1952 , vol. 35, p. 1527,1533
反应条件
hydrogen bromide; acetic acid Erwaermen des Reaktionsprodukts in Wasser;
参考文献
Schmidle; Mansfield
Journal of the American Chemical Society, 1956 , vol. 78, p. 425,426
反应条件
manganese(IV) oxide in toluene 3 h; Heating;
参考文献
Soldatenkov; Polyanskii; Temesgen; Sergeeva; Vysotskaya; Averkiev; Antipin; Lobanov
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 5 p. 641 - 649
反应条件
male Wistar rat liver microsomes; NADPH-generating system in phosphate buffer T=37°C; oxidative N-demethylation; pH=7.4; 0.25 h; Enzyme kinetics;
参考文献
Chemical Research in Toxicology, , vol. 9, # 1 p. 93 - 98
反应条件
potassium permanganate in acetonitrile
T=20 - 60°C; 26 h;
参考文献
Soldatenkov; Temesgen; Bekro
Chemistry of Heterocyclic Compounds, 2001 , vol. 37, # 10 p. 1216 - 1222
