4-[(E)-2-(4-溴苯基)乙烯基]-N,N-二甲基-苯胺合成路线 (共 11 条)
反应条件
sodium methylate in N,N-dimethyl-formamide T=25°C; 24 h;
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; YANG, Jerry; THEODORAKIS, Emmanuel A.
Patent: WO2011/72257 A2, 2011 ;
Location in patent: Page/Page column 38-39; 42 ;
WO 2011/072257 A2
反应条件
diphenyldisulfane in tetrahydrofuran T=90°C; 7 h;
参考文献
University of Pittsburgh
Patent: US6706839 B1, 2004 ;
Location in patent: Page column 7-9 ;
反应条件
1: With potassium tert-butylate in tetrahydrofuran Wittig reaction; 2: With iodine in toluene T=110°C;
参考文献
Kulhanek, Jiri; Bures, Filip; Ludwig, Miroslav
Beilstein Journal of Organic Chemistry, 2009 , vol. 5, art. no. 11
反应条件
1: 4-bromo-benzyl bromide With triethyl phosphite T=150°C; 3 h; Inert atmosphere; 2: With sodium hydride in N,N-dimethyl-formamide; mineral oil Horner-Wadsworth-Emmons olefination; 0.333333 h; Cooling with ice; 3: 4-dimethylamino-benzaldehyde in N,N-dimethyl-formamide; mineral oil Horner-Wadsworth-Emmons olefination; 12 h;
参考文献
Gigante, Barbara; Esteves, M. Alexandra; Pires; Davies, Matthew L.; Douglas, Peter; Fonseca, Sofia M.; Burrows, Hugh D.; Castro, Ricardo A. E.; Pina, Joao; Seixas De Melo, Joao
New Journal of Chemistry, 2009 , vol. 33, # 4 p. 877 - 885
反应条件
1.1: toluene / 2 h / Heating 2.1: t-BuOK / tetrahydrofuran / 20 h / 20 °C 2.2: iodine / toluene / 4 h / Heating View Scheme
参考文献
Halton, Brian; Cooney, Mark J.
Australian Journal of Chemistry, 2006 , vol. 59, # 2 p. 118 - 122
反应条件
1.1: NBS / CCl4 / 4 h / Heating 2.1: toluene / 2 h / Heating 3.1: t-BuOK / tetrahydrofuran / 20 h / 20 °C 3.2: iodine / toluene / 4 h / Heating View Scheme
参考文献
Liu, Zhi-Qiang; Fang, Qi; Wang, Dong; Cao, Du-Xia; Xue, Gang; Yu, Wen-Tao; Lei, Hong
Chemistry - A European Journal, 2003 , vol. 9, # 20 p. 5074 - 5084
反应条件
potassium carbonate in tetrahydrofuran; dichloromethane Wittig reaction; 22 h; Heating;
参考文献
Halton, Brian; Cooney, Mark J.
Australian Journal of Chemistry, 2006 , vol. 59, # 2 p. 118 - 122
反应条件
2: P2O5; benzene View Scheme
参考文献
Tadros; Latif
Journal of the Chemical Society, 1952 , p. 3823
反应条件
2: P2O5; benzene View Scheme
参考文献
Tadros; Latif
Journal of the Chemical Society, 1952 , p. 3823
反应条件
methanol und Erwaermen des Reaktionsprodukts mit Natriumaethylat in Aethanol;
参考文献
Haddow et al.
Phil.Trans.<A>, 1948 , vol. 241, p. 147,186